: A Model System for Neurological Disorders

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Feb 15

PMID 35159273

Authors

Claire Louise Storey

Robin Simon Brooke Williams

Paul Robert Fisher

Sarah Jane Annesley

Affiliations

Soon will be listed here.

Abstract

Background: The incidence of neurological disorders is increasing due to population growth and extended life expectancy. Despite advances in the understanding of these disorders, curative strategies for treatment have not yet eventuated. In part, this is due to the complexities of the disorders and a lack of identification of their specific underlying pathologies. has provided a useful, simple model to aid in unraveling the complex pathological characteristics of neurological disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, neuronal ceroid lipofuscinoses and lissencephaly. In addition, has proven to be an innovative model for pharmaceutical research in the neurological field.

Scope Of Review: This review describes the contributions of in the field of neurological research. The continued exploration of proteins implicated in neurological disorders in may elucidate their pathological roles and fast-track curative therapeutics.

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