Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Feb 15

PMID 35159169

Authors

Md Gulam Musawwir Khan

Yi Wang

Affiliations

Soon will be listed here.

Abstract

Cells exposed to ionizing radiation undergo a series of complex responses, including DNA damage, reproductive cell death, and altered proliferation states, which are all linked to cell cycle dynamics. For many years, a great deal of research has been conducted on cell cycle checkpoints and their regulators in mammalian cells in response to high-dose exposures to ionizing radiation. However, it is unclear how low-dose ionizing radiation (LDIR) regulates the cell cycle progression. A growing body of evidence demonstrates that LDIR may have profound effects on cellular functions. In this review, we summarize the current understanding of how LDIR (of up to 200 mGy) regulates the cell cycle and cell-cycle-associated proteins in various cellular settings. In light of current findings, we also illustrate the conceptual function and possible dichotomous role of p21, a transcriptional target of p53, in response to LDIR.

Citing Articles

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Effects of Low Dose Neutron-Gamma Field on Cell Cycle and Damage of Human Lymphocytes.

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