Longitudinal Analysis of 1α,25-dihidroxyvitamin D and Homocysteine Changes in Colorectal Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Feb 15

PMID 35158926

Authors

Dorottya Muhl

Magdolna Herold

Zoltan Herold

Lilla Hornyak

Attila Marcell Szasz

Magdolna Dank

Affiliations

Soon will be listed here.

Abstract

Background: 1α,25-dihydroxycholecalciferol (1,25(OH)D) and homocysteine are known to play a role in the pathophysiology of colorectal cancer (CRC). In health, the two changes are inversely proportional to each other, but little is known about their combined effect in CRC.

Methods: The serum 1,25(OH)D and the homocysteine levels of eighty-six CRC patients were measured, who were enrolled into four cohorts based on the presence of metastases (Adj vs. Met) and vitamin D supplementation (ND vs. D).

Results: 1,25(OH)D was constant (Adj-ND), increased significantly (Adj-D, = 0.0261), decreased (Met-ND), or returned close to the baseline after an initial increase (Met-D). The longitudinal increase in 1,25(OH)D (HR: 0.9130, = 0.0111) positively affected the overall survival in non-metastatic CRC, however, this effect was cancelled out in those with metastasis ( = 0.0107). The increase in homocysteine negatively affected both the overall (HR: 1.0940, = 0.0067) and the progression-free survival (HR: 1.0845, = 0.0073). Lower 1,25(OH)D and/or higher homocysteine level was characteristic for patients with higher serum lipids, albumin, total protein, white blood cell and platelet count, male sex, and right-sided tumors. No statistically justifiable connection was found between the target variables.

Conclusions: A measurement-based titration of vitamin D supplementation and better management of comorbidities are recommended for CRC.

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