[Amiodarone: Some Toxicity Considerations]

Amiodarone is a class III antiarrhythmic drug effective in the treatment of ventricular arrhythmias and atrial fibrillation. The prolonged half-life and lipo-solubility are responsible for its accumulation in tissues and its toxicity ranges from mild to severe. Main adverse effects are observed on thyroid, pulmonary and cardiac system. Clinical and biological monitoring allows early detection of their occurrence. In case of serious side effect, treatment discontinuation is often necessary and therapeutic alternatives must be considered.