Synthesis and Toxicological Effect of Some New Pyrrole Derivatives As Prospective Insecticidal Agents Against the Cotton Leafworm, (Boisduval)

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Feb 14

PMID 35155894

Authors

Antar A Abdelhamid

Kaoud S M Salama

Ahmed M Elsayed

Mohamed A Gad

Mahmoud Abd El Aleem Ali Ali El-Remaily

Affiliations

Soon will be listed here.

Abstract

Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1-pyrrol-2-yl)thio]acetic acids , 2-[(2-hydroxyethyl)-thio]-5-aryl-1-pyrrole-3-carbonitriles , and 2-[(2-amino-ethyl)thio]-5-aryl-1-pyrrole-3-carbonitriles , 2,2'-disulfanediylbis(5-aryl-1-pyrrole-3-carbonitriles) , 2-((3-cyano-5-aryl-1-pyrrol-2-yl)thio)acetates , 2-[(3-cyano-5-phenyl-1-pyrrol-2-yl)thio]acetohydrazides , and 2-{2-[(3-cyano-5-aryl-1-pyrrol-2-yl)thio]acetyl}--phenyl-hydrazinecarbothioamides , as insecticidal agents, were synthesized via adaptable, smoothly accessible 2-(2-oxo-2-arylylethyl)malononitriles . The structures were proved using infrared (IR), nuclear magnetic resonance (NMR), and mass spectrum (MS) techniques. Under laboratory conditions, the toxicological characteristics were tested towards , cotton leafworm insect type. In respect to the LC values, compounds , , , and possess the highest insecticidal bioefficacy, with values of 0.5707, 0.1306, 0.9442, and 5.883 ppm, respectively. The study paves the way towards discovering new materials for potential use as insecticidal active agents.

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