The Correlation and Role Analysis of SLC30A1 and SLC30A10 in Cervical Carcinoma

Overview

Journal J Cancer

Specialty Oncology

Date 2022 Feb 14

PMID 35154468

Authors

Jing Zhang

Xin-Wei Chen

Li-Sha Shu

Chong-Dong Liu

Affiliations

Soon will be listed here.

Abstract

: SLC30 family genes, also known as ZnT family genes, can keep cellular zinc levels within a physiological range by exporting zinc to extracellular space or by isolating zinc in the specific regions of cytoplasm when cellular zinc concentrations are elevated in human cells. There are growing evidences that dysregulated expression of SLC30 family genes can potentially influence tumorigenesis. However, the expression and prognostic value of SLC30 family genes in cervical carcinoma are poorly characterized. : In this study, we used many tools such as UALCAN, Kaplan-Meier Plotter, cBioPortal, LinkedOmics, FunRich, Metascape, GeneMANIA, Open targets and TISIDB to perform bioinformatics analysis of SLC30 family genes in cervical carcinoma. We found that the expression of SLC30A1/7/10 was significantly higher in cervical carcinoma than that in normal matched tissues, while SLC30A2/8 mRNA levels were decreased compared to normal tissues. For tumor stages, SLC30A1, SLC30A7 and SLC30A10 groups significantly varied. And a high expression of SLC30A1, SLC30A6, SLC30A8 and SLC30A10 was associated with worse overall survival in cervical carcinoma patients. Besides, we found that SLC30A1/10 may have a potential regulatory role in immune infiltration in cervical carcinoma. In addition, the results showed that the high expression of SLC30A1 was resistant to 79 drugs or small molecules; Two drugs (Neopeltolide and Tozasertib) can inhibit the high expression of SLC30A10 in cancers. : SLC30A1 and SLC30A10 can be recognized as potential diagnostic indicators and therapeutic targets in cervical carcinoma.

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References

Liu Y, Liu T, Jin H, Yin L, Yu H, Bi J . MiR-411 suppresses the development of bladder cancer by regulating ZnT1. Onco Targets Ther. 2018; 11:8695-8704. PMC: 6287661. DOI: 10.2147/OTT.S173750. View

Guo Y, He Y . Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer. Sci Rep. 2020; 10(1):18352. PMC: 7591519. DOI: 10.1038/s41598-020-75012-w. View

Zhang X, Liang D, Guo B, Deng W, Chi Z, Cai Y . Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. Cell Signal. 2013; 25(4):999-1010. DOI: 10.1016/j.cellsig.2012.12.013. View

Henshall S, Afar D, Rasiah K, Horvath L, Gish K, Caras I . Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer. Oncogene. 2003; 22(38):6005-12. DOI: 10.1038/sj.onc.1206797. View

. Comprehensive molecular portraits of human breast tumours. Nature. 2012; 490(7418):61-70. PMC: 3465532. DOI: 10.1038/nature11412. View

Nagy A, Lanczky A, Menyhart O, Gyorffy B . Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018; 8(1):9227. PMC: 6003936. DOI: 10.1038/s41598-018-27521-y. View

Zhang L, Wang Y, Wang L . MiRNA-8073 targets ZnT1 to inhibit malignant progression of ovarian cancer. Eur Rev Med Pharmacol Sci. 2019; 23(14):6062-6069. DOI: 10.26355/eurrev_201907_18419. View

Koscielny G, An P, Carvalho-Silva D, Cham J, Fumis L, Gasparyan R . Open Targets: a platform for therapeutic target identification and validation. Nucleic Acids Res. 2016; 45(D1):D985-D994. PMC: 5210543. DOI: 10.1093/nar/gkw1055. View

Szklarczyk D, Gable A, Lyon D, Junge A, Wyder S, Huerta-Cepas J . STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2018; 47(D1):D607-D613. PMC: 6323986. DOI: 10.1093/nar/gky1131. View

10.

Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M . Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis. Mol Cancer Res. 2018; 16(3):554-563. DOI: 10.1158/1541-7786.MCR-17-0393. View

11.

Bostanci Z, Alam S, Soybel D, Kelleher S . Prolactin receptor attenuation induces zinc pool redistribution through ZnT2 and decreases invasion in MDA-MB-453 breast cancer cells. Exp Cell Res. 2013; 321(2):190-200. DOI: 10.1016/j.yexcr.2013.12.005. View

12.

Wang T, Chen X, Qiao W, Kong L, Sun D, Li Z . Transcription factor E2F1 promotes EMT by regulating ZEB2 in small cell lung cancer. BMC Cancer. 2017; 17(1):719. PMC: 5678576. DOI: 10.1186/s12885-017-3701-y. View

13.

Li L, Gai X . The association between dietary zinc intake and risk of pancreatic cancer: a meta-analysis. Biosci Rep. 2017; 37(3). PMC: 5463257. DOI: 10.1042/BSR20170155. View

14.

Pathan M, Keerthikumar S, Ang C, Gangoda L, Quek C, Williamson N . FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics. 2015; 15(15):2597-601. DOI: 10.1002/pmic.201400515. View

15.

Cho W, Kim Y, Park W, Yang K, Kim H, Cha H . Para-aortic lymph node recurrence after curative radiotherapy for cervical cancer. Int J Gynecol Cancer. 2019; 29(7):1116-1120. DOI: 10.1136/ijgc-2019-000615. View

16.

Chandrashekar D, Bashel B, Balasubramanya S, Creighton C, Ponce-Rodriguez I, Chakravarthi B . UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. Neoplasia. 2017; 19(8):649-658. PMC: 5516091. DOI: 10.1016/j.neo.2017.05.002. View

17.

Cohen P, Jhingran A, Oaknin A, Denny L . Cervical cancer. Lancet. 2019; 393(10167):169-182. DOI: 10.1016/S0140-6736(18)32470-X. View

18.

Ru B, Wong C, Tong Y, Zhong J, Zhong S, Wu W . TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019; 35(20):4200-4202. DOI: 10.1093/bioinformatics/btz210. View

19.

Zhao Y, Feresin R, Falcon-Perez J, Salazar G . Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity. Traffic. 2016; 17(3):267-88. DOI: 10.1111/tra.12371. View

20.

Warde-Farley D, Donaldson S, Comes O, Zuberi K, Badrawi R, Chao P . The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010; 38(Web Server issue):W214-20. PMC: 2896186. DOI: 10.1093/nar/gkq537. View