The Isolation and Nucleotide Sequence of the Complex AROM Locus of Aspergillus Nidulans

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1986 Mar 11

PMID 3515316

Citations 46

Authors

I G Charles

J W Keyte

W J Brammar

M Smith

A R Hawkins

Affiliations

Soon will be listed here.

Abstract

The AROM locus of A. nidulans, which governs five consecutive steps in pre-chorismate aromatic amino acid biosynthesis, has been cloned in a bacteriophage vector. The nucleotide sequence of the locus reveals a single, open reading-frame of 4,812 base-pairs, apparently without introns. An internal segment of the A. nidulans AROM sequence has extensive homology with the E. coli aroA gene that encodes the 5-enolpyruvylshikimate 3-phosphate synthase.

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