Urinary Tract Infection in Parkinson's Disease

Overview

Journal J Parkinsons Dis

Publisher Sage Publications

Specialty Neurology

Date 2022 Feb 11

PMID 35147552

Authors

Elliot Hogg

Samuel Frank

Jillian Oft

Brian Benway

Mohammad Harun Rashid

Shouri Lahiri

Affiliations

Soon will be listed here.

Abstract

Urinary tract infection (UTI) is a common precipitant of acute neurological deterioration in patients with Parkinson's disease (PD) and a leading cause of delirium, functional decline, falls, and hospitalization. Various clinical features of PD including autonomic dysfunction and altered urodynamics, frailty and cognitive impairment, and the need for bladder catheterization contribute to an increased risk of UTI. Sepsis due to UTI is a feared consequence of untreated or undertreated UTI and a leading cause of morbidity in PD. Emerging research suggests that immune-mediated brain injury may underlie the pathogenesis of UTI-induced deterioration of PD symptoms. Existing strategies to prevent UTI in patients with PD include use of topical estrogen, prophylactic supplements, antibiotic bladder irrigation, clean catheterization techniques, and prophylactic oral antibiotics, while bacterial interference and vaccines/immunostimulants directed against common UTI pathogens are potentially emerging strategies that are currently under investigation. Future research is needed to mitigate the deleterious effects of UTI in PD.

Citing Articles

Infections in the Etiology of Parkinson's Disease and Synucleinopathies: A Renewed Perspective, Mechanistic Insights, and Therapeutic Implications.

Mercado G, Kaeufer C, Richter F, Peelaerts W J Parkinsons Dis. 2024; 14(7):1301-1329.

PMID: 39331109 PMC: 11492057. DOI: 10.3233/JPD-240195.

Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy.

Lewis F, Shoieb D, Azmoun S, Colicino E, Jin Y, Chi J medRxiv. 2024; .

PMID: 39281765 PMC: 11398432. DOI: 10.1101/2024.09.04.24313002.

Impact of autonomic symptoms on the clinical course of Parkinson's disease.

Fujita H, Ogaki K, Shiina T, Sakuramoto H, Nozawa N, Suzuki K Neurol Sci. 2024; 45(8):3799-3807.

PMID: 38400889 DOI: 10.1007/s10072-024-07422-x.

Complications and outcomes of hospitalizations for patients with and without Parkinson disease.

George B, Barbosa W, Sethi A, Richard I Front Aging Neurosci. 2024; 15:1276731.

PMID: 38161593 PMC: 10757345. DOI: 10.3389/fnagi.2023.1276731.

Mortality rates and proximal causes of death in patients with Lewy body dementia versus Alzheimer's disease: A longitudinal study using secondary care mental health records.

Kershenbaum A, Price A, Cardinal R, Chen S, FitzGerald J, Lewis J Int J Geriatr Psychiatry. 2023; 38(5):e5937.

PMID: 37208979 PMC: 10946736. DOI: 10.1002/gps.5937.

References

Leung T, Lui C, Chen L, Yung W, Chan Y, Yung K . Ceftriaxone ameliorates motor deficits and protects dopaminergic neurons in 6-hydroxydopamine-lesioned rats. ACS Chem Neurosci. 2012; 3(1):22-30. PMC: 3369786. DOI: 10.1021/cn200072h. View

MacLullich A, Ferguson K, Miller T, de Rooij S, Cunningham C . Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res. 2008; 65(3):229-38. PMC: 4311661. DOI: 10.1016/j.jpsychores.2008.05.019. View

Factor S, Molho E . Emergency department presentations of patients with Parkinson's disease. Am J Emerg Med. 2000; 18(2):209-15. DOI: 10.1016/s0735-6757(00)90023-8. View

Segal O, Hassin-Baer S, Rosman M, Segal G . Decreased dopaminergic treatment of hospitalized Parkinson's disease patients during infectious diseases is associated with poor outcomes. J Clin Neurosci. 2015; 22(8):1272-4. DOI: 10.1016/j.jocn.2015.02.010. View

Vince K, Insall J, Bannerman C . Total knee arthroplasty in the patient with Parkinson's disease. J Bone Joint Surg Br. 1989; 71(1):51-4. DOI: 10.1302/0301-620X.71B1.2915005. View

Berger Y, Blaivas J, DeLaRocha E, Salinas J . Urodynamic findings in Parkinson's disease. J Urol. 1987; 138(4):836-8. DOI: 10.1016/s0022-5347(17)43390-8. View

Sunden F, Hakansson L, Ljunggren E, Wullt B . Escherichia coli 83972 bacteriuria protects against recurrent lower urinary tract infections in patients with incomplete bladder emptying. J Urol. 2010; 184(1):179-85. DOI: 10.1016/j.juro.2010.03.024. View

Van Pham T, Kreis B, Bauer J, Mauel J . Metabolic and functional stimulation of lymphocytes and macrophages by an Escherichia coli extract (OM-89): in vitro studies. J Biol Response Mod. 1990; 9(2):231-40. View

Bauer H, Alloussi S, Egger G, Blumlein H, Cozma G, Schulman C . A long-term, multicenter, double-blind study of an Escherichia coli extract (OM-89) in female patients with recurrent urinary tract infections. Eur Urol. 2005; 47(4):542-8. DOI: 10.1016/j.eururo.2004.12.009. View

10.

Maki D, Tambyah P . Engineering out the risk for infection with urinary catheters. Emerg Infect Dis. 2001; 7(2):342-7. PMC: 2631699. DOI: 10.3201/eid0702.010240. View

11.

Miller D, Lovell E . Antibiotic-induced serotonin syndrome. J Emerg Med. 2008; 40(1):25-7. DOI: 10.1016/j.jemermed.2007.10.072. View

12.

Pott Godoy M, Tarelli R, Ferrari C, Sarchi M, Pitossi F . Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain. 2008; 131(Pt 7):1880-94. PMC: 2442423. DOI: 10.1093/brain/awn101. View

13.

Parashar A, Udayabanu M . Gut microbiota: Implications in Parkinson's disease. Parkinsonism Relat Disord. 2017; 38:1-7. PMC: 7108450. DOI: 10.1016/j.parkreldis.2017.02.002. View

14.

Kaye D . Host defense mechanisms in the urinary tract. Urol Clin North Am. 1975; 2(3):407-22. View

15.

Temlett J, Thompson P . Reasons for admission to hospital for Parkinson's disease. Intern Med J. 2006; 36(8):524-6. DOI: 10.1111/j.1445-5994.2006.01123.x. View

16.

Clarke C . Has drug therapy changed the natural history of Parkinson's disease?. J Neurol. 2010; 257(Suppl 2):S262-7. DOI: 10.1007/s00415-010-5716-z. View

17.

Schaeffer A, Stuppy B . Efficacy and safety of self-start therapy in women with recurrent urinary tract infections. J Urol. 1999; 161(1):207-11. View

18.

Nickel J, Stephens A, Landis J, Mullins C, Van Bokhoven A, Lucia M . Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol. 2015; 195(2):356-62. PMC: 4770794. DOI: 10.1016/j.juro.2015.09.075. View

19.

Kim C, Lv G, Lee J, Jung B, Masuda-Suzukake M, Hong C . Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril. Sci Rep. 2016; 6:30891. PMC: 4973277. DOI: 10.1038/srep30891. View

20.

Schmidhammer S, Ramoner R, Holtl L, Bartsch G, Thurnher M, Zelle-Rieser C . An Escherichia coli-based oral vaccine against urinary tract infections potently activates human dendritic cells. Urology. 2002; 60(3):521-6. DOI: 10.1016/s0090-4295(02)01767-3. View