Annexin-A1: The Culprit or the Solution?

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2022 Feb 11

PMID 35146757

Authors

Lauren Kelly

Sarah McGrath

Lewis Rodgers

Kathryn McCall

Aysin Tulunay Virlan

Fiona Dempsey

Scott Crichton

Carl S Goodyear

Affiliations

Soon will be listed here.

Abstract

Annexin-A1 has a well-defined anti-inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid-induced protein has been implicated in a range of inflammatory conditions and cancers, as well as being found to be overexpressed on the T cells of patients with autoimmune disease. Moreover, the formyl peptide family of receptors, through which annexin-A1 primarily signals, has also been implicated in these diseases. In contrast, treatment with recombinant annexin-A1 peptides resulted in suppression of inflammatory processes in murine models of inflammation. This review will focus on what is currently known about annexin-A1 in health and disease and discuss the potential of this protein as a biomarker and therapeutic target.

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