Iatrogenic Spinal Cord Ischemia: A Patient Level Meta-analysis of 74 Case Reports and Series

Overview

Journal N Am Spine Soc J

Date 2022 Feb 10

PMID 35141645

Authors

Anant Naik

Christina M Moawad

Samantha L Houser

T Kesh Kesavadas

Paul M Arnold

Affiliations

Soon will be listed here.

Abstract

Background: We seek to characterize the features of iatrogenic spinal ischemia, determine which spinal levels are affected, and evaluate the efficacy of management strategies.

Methods: We performed a meta-analysis of case reports and series of spinal ischemia in the past 10 years. 343 full-length case reports and case series were screened against predefined inclusion/exclusion criteria. 89 patients were included for our final meta-analysis using PRISMA guidelines.

Results: Mean age of patients was 59.62 years (range: 9 months-88 years). 66% of all cases were male. Endovascular surgery (32.6%) and aortic surgery (36.0%) were most common causes of iatrogenic injury, followed by non-aortic surgery (32.6%), and non-surgical procedures (22.47%). A- and B-level ASIA Impairment was found in 66% of all patients. Rehabilitation was the most common management (49.44% of cases), followed by blood pressure management (40.45%). Non-aortic surgeries had the poorest overall outcomes (OR = 0.28, = 0.016), whereas aortic and endovascular surgeries saw significant improvement in outcomes measured at discharge (OR = 2.6, OR = 2.3, respectively, < 0.05). Therapeutic surgical infarctions were found to be associated with improved outcomes (OR = 5.33, = 0.032). Ischemic injury to T4-T7, and T10 were associated with significantly poorer outcomes. Autonomic impairment was associated with a likelihood of infarction at T10 (OR = 4.54, = 0.0183).

Conclusions: In this paper, we compare outcomes following iatrogenic spinal ischemia. We demonstrate the need for more comprehensive randomized controlled trials to test effective treatment strategies.

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