Comparison of Tendon Development Versus Tendon Healing and Regeneration

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Feb 10

PMID 35141224

Authors

Peiwen He

Dengfeng Ruan

Zizhan Huang

Canlong Wang

Yiwen Xu

Honglu Cai

Hengzhi Liu

Yang Fei

Boon Chin Heng

Weishan Chen

Weiliang Shen

Affiliations

Soon will be listed here.

Abstract

Tendon is a vital connective tissue in human skeletal muscle system, and tendon injury is very common and intractable in clinic. Tendon development and repair are two closely related but still not fully understood processes. Tendon development involves multiple germ layer, as well as the regulation of diversity transcription factors (Scx et al.), proteins (Tnmd et al.) and signaling pathways (TGFβ et al.). The nature process of tendon repair is roughly divided in three stages, which are dominated by various cells and cell factors. This review will describe the whole process of tendon development and compare it with the process of tendon repair, focusing on the understanding and recent advances in the regulation of tendon development and repair. The study and comparison of tendon development and repair process can thus provide references and guidelines for treatment of tendon injuries.

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