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The Challenges and Optimization of Cell-based Therapy for Cardiovascular Disease

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Publisher Sciendo
Specialty General Medicine
Date 2022 Feb 9
PMID 35136722
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Abstract

With the hope of achieving real cardiovascular repair, cell-based therapy raised as a promising strategy for the treatment of cardiovascular disease (CVD) in the past two decades. Various types of cells have been studied for their reparative potential for CVD in the ensuing years. Despite the exciting results from animal experiments, the outcome of clinical trials is unsatisfactory and the development of cell-based therapy for CVD has hit a plateau nowadays. Thus, it is important to summarize the obstacles we are facing in this field in order to explore possible solutions for optimizing cell-based therapy and achieving real clinical application.

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References
1.
He F, Luo P, Tang T, Zhang F, Fang H, Ji S . Targeted release of stromal cell-derived factor-1α by reactive oxygen species-sensitive nanoparticles results in bone marrow stromal cell chemotaxis and homing, and repair of vascular injury caused by electrical burns. PLoS One. 2018; 13(3):e0194298. PMC: 5847229. DOI: 10.1371/journal.pone.0194298. View

2.
Narita A, Takahara M, Sato D, Ogino T, Fukushima S, Kimura Y . Biodegradable gelatin hydrogels incorporating fibroblast growth factor 2 promote healing of horizontal tears in rabbit meniscus. Arthroscopy. 2011; 28(2):255-63. DOI: 10.1016/j.arthro.2011.08.294. View

3.
Segal M, Shah R, Afzal A, Perrault C, Chang K, Schuler A . Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Diabetes. 2005; 55(1):102-9. View

4.
Dimmeler S, Ding S, Rando T, Trounson A . Translational strategies and challenges in regenerative medicine. Nat Med. 2014; 20(8):814-21. DOI: 10.1038/nm.3627. View

5.
Stamm C, Nasseri B, Choi Y, Hetzer R . Cell therapy for heart disease: great expectations, as yet unmet. Heart Lung Circ. 2009; 18(4):245-56. DOI: 10.1016/j.hlc.2008.10.014. View