Usual Interstitial Pneumonia Pattern Interstitial Lung Disease Developed in a Patient with IgG4-related Chronic Sclerosing Sialadenitis

Overview

Journal Intern Med

Specialty General Medicine

Date 2022 Feb 9

PMID 35135925

Authors

Hiroshi Yamamoto

Masamichi Komatsu

Kei Sonehara

Yuichi Ikuyama

Kazuhisa Urushihata

Kazunari Tateishi

Yoshiaki Kitaguchi

Atsuhito Ushuiki

Shiho Asaka

Takeshi Uehara

Satoshi Kawakami

Kentaro Mori

Kazutoshi Hamanaka

Kenichi Nishie

Akira Hebisawa

Masayuki Hanaoka

Affiliations

Soon will be listed here.

Abstract

A 69-year-old man was diagnosed with immunoglobulin (Ig) G4-related disease (IgG4-RD) at 62 years old. At that time, he had high serum IgG4 levels and bilateral submandibular gland swelling on CT; thus, a gland biopsy was performed. Because a reticular shadow was found on chest CT, a lung surgical biopsy was also performed. The specimens revealed usual interstitial pneumonia (UIP) pattern interstitial pneumonia with some IgG4-positive cells. The patient was subsequently followed up without treatment. His forced vital capacity and radiological findings progressively deteriorated, consistent with UIP pattern interstitial lung disease but different from a lung lesion of IgG4-RD.

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