Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis

Overview

Journal Can Respir J

Publisher Wiley

Specialty Pulmonary Medicine

Date 2022 Feb 8

PMID 35132344

Authors

Songul Ozyurt

Neslihan Ozcelik

Bilge Yilmaz Kara

Medeni Arpa

Yavuz Metin

Ozcan Erel

Salim Neselioglu

Affiliations

Soon will be listed here.

Abstract

Purpose: Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls.

Materials And Methods: Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (-SH); TT: total thiol (-SH + SS); SS: disulfide (-SS); SS-SH: disulfide/native thiol index; SS-TT: disulphide/total thiol index; SH-TT: native thiol/total thiol index), and ischemia-modified albumin (IMA) levels were examined in the stable bronchiectasis group and the control group. Thiol-disulfide homeostasis was evaluated using a novel and automated assay. . Blood native thiol levels in patients with stable bronchiectasis were found to be significantly higher compared with healthy controls. A positive correlation between the total airway disease score and IMA levels was present. Our findings revealed that native thiol levels, which constitute a part of the antioxidant defense system, are increased in patients with stable bronchiectasis.

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