Epigenetics in the Pathogenesis of Diabetic Nephropathy

Overview

Journal Acta Biochim Biophys Sin (Shanghai)

Specialties Biochemistry
Biophysics

Date 2022 Feb 7

PMID 35130617

Authors

Xue Li

Lihong Lu

Wenting Hou

Ting Huang

Xiangyuan Chen

Jie Qi

Yanjun Zhao

Minmin Zhu

Affiliations

Soon will be listed here.

Abstract

Diabetic nephropathy (DN), which is a common microvascular complication with a high incidence in diabetic patients, greatly increases the mortality of patients. With further study on DN, it is found that epigenetics plays a crucial role in the pathophysiological process of DN. Epigenetics has an important impact on the development of DN through a variety of mechanisms, and promotes the generation and maintenance of metabolic memory, thus ultimately leading to a poor prognosis. In this review we discuss the methylation of DNA, modification of histone, and regulation of non-coding RNA involved in the progress of cell dysfunction, inflammation and fibrosis in the kidney, which ultimately lead to the deterioration of DN.

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