Oxidative Stress and DNA Damage Status in Couples Undergoing Fertilization Treatment

Overview

Journal Reprod Fertil

Specialty Reproductive Medicine

Date 2022 Feb 7

PMID 35128448

Authors

Iman Al-Saleh

Serdar Coskun

Reem Al-Rouqi

Tahreer Al-Rajudi

Chafica Eltabache

Mai Abduljabbar

Saad Al-Hassan

Affiliations

Soon will be listed here.

Abstract

Lay Summary: Oxidative stress occurs when antioxidant molecules are insufficient in the body to destroy free radicals that can damage the cells, proteins and DNA, causing different health conditions, including infertility. The role of oxidative stress in female infertility has not received as much attention as male infertility, and research is still limited. This study explored whether the overproduction of free radicals can impact the success of fertilization (IVF) treatment using several biological markers such as hydrogen peroxide, catalase, and total antioxidant capacity. Our findings revealed that the high antioxidant levels in the fluid surrounding the egg were linked with a high fertilization rate. Additionally, oxidative stress status in couples was associated negatively with several reproductive hormones and smoking status. Biomarkers of oxidative stress and DNA damage might have potential applications in evaluating IVF patients' clinical characteristics such as causes of infertility, hormonal profile, fertilization rate, implantation and live birth.

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