Micro RNAs As Potential Biomarkers in Tuberculosis: A Systematic Review

Overview

Journal Noncoding RNA Res

Date 2022 Feb 7

PMID 35128217

Authors

Bijay Pattnaik

Niharika Patnaik

Saurabh Mittal

Anant Mohan

Anurag Agrawal

Randeep Guleria

Karan Madan

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB) remains a major infectious disease across the globe. With increasing TB infections and a rise in multi-drug resistance, rapid diagnostic modalities are required to achieve TB control. Radiological investigations and microbiological tests (microscopic examination, cartridge-based nucleic acid amplification tests, and cultures) are most commonly used to diagnose TB. Histopathological/cytopathological examinations are also required for an accurate diagnosis in many patients. The causative agent, (Mtb), is known to circumvent the host's immune system. Circulating microRNAs (miRNAs) play a crucial role in biological pathways and can be used as a potential biomarker to detect tuberculosis. miRNAs are small non-coding RNAs and negatively regulate gene expression during post-transcriptional regulation. The differential expression of miRNAs in multiple clinical samples in tuberculosis patients may be helpful as potential disease biomarkers. This review summarizes the literature on miRNAs in various clinical samples as biomarkers for TB diagnosis.

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