Nonhormonal Therapy for Endometriosis Based on Energy Metabolism Regulation

Overview

Journal Reprod Fertil

Specialty Reproductive Medicine

Date 2022 Feb 4

PMID 35118411

Authors

Hiroshi Kobayashi

Hiroshi Shigetomi

Shogo Imanaka

Affiliations

Soon will be listed here.

Abstract

Lay Summary: The most commonly used medical therapies for endometriosis have contraceptives and other side effects associated with hormone suppression and are therefore unsuitable for women desiring pregnancy. One therapeutic strategy that may avoid hormone manipulation is focused on changing metabolic profiles that have been detected in cells/tissues from women with endometriosis. Endometriotic cells favor glycolytic metabolism over mitochondrial oxidative phosphorylation (OXPHOS) to produce essential energy for cell growth. Furthermore, the metabolic conversion from mitochondrial OXPHOS to aerobic glycolysis suppresses cell death through the reduced generation of reactive oxygen species (ROS). This unique metabolic feature of endometriosis is important for cell survival and disease progression. Thus, changing the specific metabolic switch may increase mitochondrial ROS production, causing severe oxidative stress and cell death. This review describes new treatments by changing the metabolic profiles of endometriosis.

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