Retrospective Study of Risk Factors for Colorectal Adenomas and Non-adenomatous Polyps

Overview

Journal Transl Cancer Res

Specialty Oncology

Date 2022 Feb 4

PMID 35117515

Authors

Guanqun Chao

Yue Zhu

Lizheng Fang

Affiliations

Soon will be listed here.

Abstract

Background: To clarify the risk factors of colorectal adenomas and non-adenomatous polyps by retrospective analysis.

Methods: Data were obtained from subjects who underwent health examination in the Health Promotion Centre of Sir Run Run Shaw Hospital of Zhejiang University from January 2016 to December 2018, and all of them completed colonoscopies. Statistical analysis was performed using R software.

Results: A total of 721 subjects were included in the analysis, of whom 58 (8.0%) were diagnosed as non-adenomatous polyps, 115 (16.0%) as adenomas, 3 (0.4%) as neuroendocrine neoplasms or adenocarcinomas. The gender ratio and prevalence of fatty liver in the non-adenomatous polyp group were different from that in the control group, and age, body mass index (BMI), waist circumference, blood glucose, serum uric acid, triglyceride, alanine transaminase and creatinine levels were higher, while the level of high-density lipoprotein was lower than control group (P<0.05). The sex ratio in the adenoma group was different from that in the control group, age, BMI, waist circumference, glycosylated hemoglobin, serum uric acid, triglyceride and creatinine levels were higher (P<0.05). Age was a risk factor for non-adenomatous polyps. Male and age were risk factors for adenomas.

Conclusions: Age, body weight, waist circumference, blood lipid and blood glucose are related to the high incidence of colorectal adenomas and non-adenomatous polyps; fatty liver is related to the high incidence of colorectal non-adenomatous polyps; age is a risk factor for non-adenomatous polyps; age and male are risk factors for colorectal adenomas.

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