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An Uncommon Recurrent Metastasis of Ovarian Immature Teratoma to the Small Bowel

Overview
Journal Case Rep Oncol
Publisher Karger
Specialty Oncology
Date 2022 Feb 3
PMID 35111017
Authors
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Abstract

Immature ovarian teratomas are rare ovarian germ cell tumors associated with a variable potential of distant metastasis. The acquisition of mature phenotypes upon post-treatment recurrence of immature teratomas has been previously described. In this study, we report, for the first time, a rare case of a recurrent ovarian immature teratoma with mature deposits in the small bowel. An incidental pelvi-abdominal mass was identified in a 30-year-old pregnant patient during antenatal ultrasonography. The mass, which was resected through salpingo-oopherectomy, was histopathologically characterized as an immature teratoma of grade 2 and treated with 3 cycles of chemotherapy. After 3 years of completing treatment, the patient suffered from severe anemia which was investigated by capsule endoscopy that identified a bleeding source in the ileum. Imaging studies revealed an intrabdominal mass that was resected laparoscopically. The pathological assessment of the mass identified a submucosal/intramuscular teratoma with mature elements indicative of a recurrent metastasis of immature teratoma associated with post-chemotherapy retroconversion. The secondary mass was then managed with adjuvant chemotherapy.

Citing Articles

Immature Teratoma: Diagnosis and Management-A Review of the Literature.

Moraru L, Mitranovici M, Chiorean D, Coros M, Moraru R, Oala I Diagnostics (Basel). 2023; 13(9).

PMID: 37174909 PMC: 10177811. DOI: 10.3390/diagnostics13091516.

References
1.
Debuquoy C, Romeo C, Vanacker H, Ray-Coquard I . Rare ovarian tumors: an update on diagnosis and treatment. Int J Gynecol Cancer. 2020; 30(6):879-887. DOI: 10.1136/ijgc-2020-001235. View

2.
Vicus D, Beiner M, Clarke B, Klachook S, Le L, Laframboise S . Ovarian immature teratoma: treatment and outcome in a single institutional cohort. Gynecol Oncol. 2011; 123(1):50-3. DOI: 10.1016/j.ygyno.2011.06.037. View

3.
Amsalem H, Nadjari M, Prus D, Hiller N, Benshushan A . Growing teratoma syndrome vs chemotherapeutic retroconversion: case report and review of the literature. Gynecol Oncol. 2004; 92(1):357-60. DOI: 10.1016/j.ygyno.2003.10.024. View

4.
Byun J, Choi I, Han M, Lee S, Roh M, Cha M . Soft tissue metastasis of an immature teratoma of the ovary. J Obstet Gynaecol Res. 2011; 37(11):1689-93. DOI: 10.1111/j.1447-0756.2011.01553.x. View

5.
Swartjes J, de Blok S, Blaauwgeers J . Abdominal wall metastases after surgical resection of an immature teratoma of the ovary. Eur J Obstet Gynecol Reprod Biol. 1997; 74(1):41-3. DOI: 10.1016/s0301-2115(97)02758-9. View