The Utility of Neutrophil Gelatinase-Associated Lipocalin in the Detection of Emerging Lung Injury Due to Mechanical Ventilation in Children: A Preliminary Study

Overview

Journal Turk Arch Pediatr

Publisher Aves

Specialty Pediatrics

Date 2022 Feb 3

PMID 35110076

Authors

Celebi Kocaoglu

Affiliations

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Abstract

Objective: Lung injuries are mostly ignored in patients supported by mechanical ventilation. Neutrophil gelatinase-associated lipocalin has come into prominence as an early sensitive and highly predictive biomarker of inflammation. The purpose of the study was to assess the capability of neutrophil gelatinase-associated lipocalin in recognizing lung injuries in children requiring mechanical ventilation.

Materials And Methods: This prospective case-controlled study was carried out in a tertiary pediatric intensive care unit. The entire study group consisted of a total of 45 patients, 15 in the patient group (supported by invasive mechanical ventilation) and 30 in the control group (self-breathing). Whether lung injuries developed or not was investigated by measuring serumneutrophil gelatinase-associated lipocalin and urine-neutrophil gelatinase-associated lipocalin levels in the course of ventilation support.

Results: In the patient group supported by mechanical ventilation, mean levels of serum-neutrophil gelatinase-associated lipocalin and urine-neutrophil gelatinase-associated lipocalin were measured as 192 ± 136.7 ng/mL and 43.7 ± 57.5 ng/mL, respectively. In the control group (self-breathing patients), mean levels of serum-neutrophil gelatinase-associated lipocalin and urine-neutrophil gelatinase-associated lipocalin were found as 144.8 ± 95 ng/mL and 39.3 ± 85 ng/mL, respectively. The levels of serum-neutrophil gelatinase-associated lipocalin were higher in those ventilated mechanically, compared to self-breathing patients. Although urineneutrophil gelatinase-associated lipocalin levels were higher among mechanically ventilated patients than the controls, the difference was not statistically significant.

Conclusion: Based on our study findings, we consider that neutrophil gelatinase-associated lipocalin may be a useful biomarker for emerging lung injuries due to mechanical ventilation in critically ill children and deserves to be investigated.

Citing Articles

Neutrophil Gelatinase-Associated Lipocalin as a Biomarker in Post-Acute COVID-19 Syndrome.

Zmudka K, Galeczka-Turkiewicz A, Wroniecka A, Wlosowicz A, Sobala-Szczygiel B, Mrochem-Kwarciak J J Clin Med. 2024; 13(7).

PMID: 38610616 PMC: 11012735. DOI: 10.3390/jcm13071851.

Utility of Neutrophil Gelatinase-Associated Lipocalin and Emerging Lung Injury: Correspondence.

Mungmunpuntipantip R, Wiwanitkit V Turk Arch Pediatr. 2022; 57(2):249-250.

PMID: 35383027 PMC: 9366162. DOI: 10.5152/TurkArchPediatr.2022.22010.

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