Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Overview

Journal Beyoglu Eye J

Publisher Kare Publishing

Specialty Ophthalmology

Date 2022 Jan 31

PMID 35098091

Authors

Tamer Takmaz

Derya Yaman

Nilay Yuksel

Mucella Arikan Yorgun

Almila Senat

Ozcan Erel

Affiliations

Soon will be listed here.

Abstract

Objectives: The thiol-disulfide balance is very important in cellular events such as apoptosis and oxidative stress. This study is a comparison of plasma thiol-disulfide homeostasis in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).

Methods: Thirty-one patients with PEXS, 43 patients with PEXG, and 38 healthy controls were included in this prospective study. The plasma level of native thiol and disulfide were measured using a spectrophotometric assay and the native thiol/disulfide ratio was analyzed.

Results: The demographic characteristics of the 3 groups were similar (p>0.05). Statistically significant differences were observed in the plasma disulfide levels (21.6±7.3 µmol/L vs. 17.4±6.8 µmol/L) and the native thiol/disulfide ratio (22.9±9.1 vs. 29.9±14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).

Conclusion: Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.

References

Schlotzer-Schrehardt U, Lommatzsch J, Kuchle M, Konstas A, Naumann G . Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2003; 44(3):1117-25. DOI: 10.1167/iovs.02-0365. View

Lutjen-Drecoll E, Shimizu T, Rohrbach M, Rohen J . Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes. Exp Eye Res. 1986; 42(5):443-55. DOI: 10.1016/0014-4835(86)90004-7. View

Turell L, Radi R, Alvarez B . The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med. 2013; 65:244-253. PMC: 3909715. DOI: 10.1016/j.freeradbiomed.2013.05.050. View

Izzotti A, Sacca S, Cartiglia C, De Flora S . Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am J Med. 2003; 114(8):638-46. DOI: 10.1016/s0002-9343(03)00114-1. View

McBean G, Aslan M, Griffiths H, Torrao R . Thiol redox homeostasis in neurodegenerative disease. Redox Biol. 2015; 5:186-194. PMC: 4434181. DOI: 10.1016/j.redox.2015.04.004. View

Yokoyama Y, Maruyama K, Yamamoto K, Omodaka K, Yasuda M, Himori N . The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage. Biochem Biophys Res Commun. 2014; 451(4):510-5. DOI: 10.1016/j.bbrc.2014.08.009. View

Naumann G, Schlotzer-Schrehardt U, Kuchle M . Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology. 1998; 105(6):951-68. DOI: 10.1016/S0161-6420(98)96020-1. View

Yimaz A, Adiguzel U, Tamer L, Yildirim O, Oz O, Vatansever H . Serum oxidant/antioxidant balance in exfoliation syndrome. Clin Exp Ophthalmol. 2005; 33(1):63-6. DOI: 10.1111/j.1442-9071.2005.00944.x. View

Biswas S, Chida A, Rahman I . Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol. 2005; 71(5):551-64. DOI: 10.1016/j.bcp.2005.10.044. View

10.

Koliakos G, Befani C, Mikropoulos D, Ziakas N, Konstas A . Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol. 2008; 246(10):1477-83. DOI: 10.1007/s00417-008-0871-y. View

11.

Tetikoglu M, Aktas S, Sagdik H, Ozcura F, Ucar F, Kocak H . Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome. Curr Eye Res. 2017; 42(6):876-879. DOI: 10.1080/02713683.2016.1256412. View

12.

Reniewska B, Mulak M, Misiuk-Hojlo M, Kostus E . [Coexistence of Alzheimer's disease with pseudoexfoliation syndrome PEX]. Klin Oczna. 2004; 106(1-2):107-9. View

13.

Sorkhabi R, Ghorbanihaghjo A, Javadzadeh A, Rashtchizadeh N, Moharrery M . Oxidative DNA damage and total antioxidant status in glaucoma patients. Mol Vis. 2011; 17:41-6. PMC: 3021573. View

14.

Tezel G . Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res. 2006; 25(5):490-513. PMC: 1820838. DOI: 10.1016/j.preteyeres.2006.07.003. View

15.

Koca M, Naumann G, Volkholz H . Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder?. Arch Ophthalmol. 1992; 110(12):1752-6. DOI: 10.1001/archopht.1992.01080240092038. View

16.

Go Y, Jones D . Cysteine/cystine redox signaling in cardiovascular disease. Free Radic Biol Med. 2010; 50(4):495-509. PMC: 3040416. DOI: 10.1016/j.freeradbiomed.2010.11.029. View

17.

Erdurmus M, Yagci R, Atis O, Karadag R, Akbas A, Hepsen I . Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma. Curr Eye Res. 2011; 36(8):713-8. DOI: 10.3109/02713683.2011.584370. View

18.

Schlotzer-Schrehardt U, Naumann G . Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol. 2006; 141(5):921-937. DOI: 10.1016/j.ajo.2006.01.047. View

19.

Yagci R, Gurel A, Ersoz I, Keskin U, Hepsen I, Duman S . Oxidative stress and protein oxidation in pseudoexfoliation syndrome. Curr Eye Res. 2006; 31(12):1029-32. DOI: 10.1080/02713680601001319. View

20.

Zoric L, Miric D, Milenkovic S, Jovanovic P, Trajkovic G . Pseudoexfoliation syndrome and its antioxidative protection deficiency as risk factors for age-related cataract. Eur J Ophthalmol. 2006; 16(2):268-73. DOI: 10.1177/112067210601600212. View