Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder

Overview

Journal ACG Case Rep J

Specialty Gastroenterology

Date 2022 Jan 31

PMID 35097149

Authors

Crista Ulteig

Kristin Ciezki

Megan Jacobson

Maharaj Sigh

Tarun Sharma

Affiliations

Soon will be listed here.

Abstract

Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well documented. We report a case series of 3 patients with coexisting esophageal dysmotility and constipation on chronic opioids that improved both symptoms after starting naloxegol. Based on these observational studies, we propose that formal studies be conducted to assess the effect of naloxegol on opioid-induced esophageal dysmotility.

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