Autosomal Recessive Spinocerebellar Ataxia Type 4 with a Mutation: A Case Report

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2022 Jan 31

PMID 35097097

Authors

Xin Huang

Dong-Sheng Fan

Affiliations

Soon will be listed here.

Abstract

Background: Autosomal recessive spinocerebellar ataxia type 4 (SCAR4) is a type of SCA that is a group of hereditary diseases characterized by gait ataxia. The main clinical features of SCAR4 are progressive cerebellar ataxia, pyramidal signs, neuropathy, and macrosaccadic intrusions. To date, many gene dysfunctions have been reported to be associated with SCAR4.

Case Summary: Here, we report a novel compound heterozygous mutation, c.3288delA (p.Asp1097ThrfsTer6), in the gene in a young female Chinese patient. The patient found something wrong with her legs about 10 years ago and presented with the typical characteristics of SCAR4 when she came to the hospital, including ataxia, neuropathy, and positive pyramidal signs. She was then diagnosed with SCAR4 and went home with symptomatic schemes.

Conclusion: SCAR4 is a hereditary disease characterized by ataxia, pyramidal signs, neuropathy, and macrosaccadic intrusions. We report a novel compound heterozygous mutation, c.3288delA (p.Asp1097ThrfsTer6), in the gene, which enriches the gene mutation spectrum and provides additional information about SCAR4.

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