Diarylamine Synthesis Via Desulfinylative Smiles Rearrangement

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2022 Jan 31

PMID 35094513

Authors

Thomas Sephton

Jonathan M Large

Sam Butterworth

Michael F Greaney

Affiliations

Soon will be listed here.

Abstract

Diarylamines are obtained directly from sulfinamides through a novel rearrangement sequence. The transformation is transition metal-free and proceeds under mild conditions, providing facile access to highly sterically hindered diarylamines that are otherwise inaccessible by traditional SAr chemistry. The reaction highlights the distinct reactivity of the sulfinamide group in Smiles rearrangements versus that of the more common sulfonamides.

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