Human Amniotic Epithelial Cells Secretome: Components, Bioactivity, and Challenges

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2022 Jan 27

PMID 35083233

Authors

Ibrahim Fathi

Toshio Miki

Affiliations

Soon will be listed here.

Abstract

Human amniotic epithelial cells (hAECs) derived from placental tissue have received significant attention as a promising tool in regenerative medicine. Several studies demonstrated their anti-inflammatory, anti-fibrotic, and tissue repair potentials. These effects were further shown to be retained in the conditioned medium of hAECs, suggesting their paracrine nature. The concept of utilizing the hAEC-secretome has thus evolved as a therapeutic cell-free option. In this article, we review the different components and constituents of hAEC-secretome and their influence as demonstrated through experimental studies in the current literature. Studies examining the effects of conditioned medium, exosomes, and micro-RNA (miRNA) derived from hAECs are included in this review. The challenges facing the application of this cell-free approach will also be discussed based on the current evidence.

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