Dengue Infection: Global Importance, Immunopathology and Management

Overview

Journal Clin Med (Lond)

Specialty General Medicine

Date 2022 Jan 26

PMID 35078789

Authors

Senanayake Abeysinghe Kularatne

Chamara Dalugama

Affiliations

Soon will be listed here.

Abstract

Dengue is an arboviral infection that is hyperendemic in tropical and subtropical climates. Clinical manifestations of dengue can range from asymptomatic infection to severe infection with multi-organ failure. Dengue haemorrhagic fever (DHF) is a subcategory in dengue infection with a hallmark of plasma leak (ie critical phase). The plasma leak in DHF is selective (pleuroperitoneal spaces), transient and dynamic, and needs careful monitoring and meticulous fluid resuscitation. In addition, dengue fever may present with extended and unusual manifestations affecting any organ, including the heart, liver, kidney and brain. Studies on vaccine development and vector control are ongoing to prevent this infection of global importance. In this article, the clinicopathological features and management aspects of dengue are discussed.

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