Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2022 Jan 25

PMID 35075377

Authors

Beili Feng

Hengdong Li

Affiliations

Soon will be listed here.

Abstract

Objective: Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis.

Methods: Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as "MMP-9", "matrix metallopeptidase-9" and "myocardial infarction", "acute myocardial infarction", "AMI", and "polymorphism". Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0.

Results: Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR = 1.49, 95%CI = 1.19-1.86, = 0.0004). Such a significance was observed in the overdominant (OR = 1.27, 95%CI = 1.14-1.41, < 0.0001) and allele genetic models (OR = 1.43, 95%CI = 1.17-1.74, = 0.0005) as well. This finding was also valid in the Asian population.

Conclusions: Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.

Citing Articles

A Biopsychosocial Model Predicting Myocardial Infarction.

Tomas J, Oliver A, Torres Z, Parker J, Marques-Sule E, Sentandreu-Mano T J Clin Med. 2023; 12(17).

PMID: 37685782 PMC: 10489059. DOI: 10.3390/jcm12175715.

Identification of Immuno-Inflammation-Related Biomarkers for Acute Myocardial Infarction Based on Bioinformatics.

You H, Dong M J Inflamm Res. 2023; 16:3283-3302.

PMID: 37576155 PMC: 10417757. DOI: 10.2147/JIR.S421196.

Matrix Metalloproteinases in Cardioembolic Stroke: From Background to Complications.

Wysocka A, Szczygielski J, Kopanska M, Oertel J, Glowniak A Int J Mol Sci. 2023; 24(4).

PMID: 36835040 PMC: 9959608. DOI: 10.3390/ijms24043628.

Rare Variants in Genes of the Cholesterol Pathway Are Present in 60% of Patients with Acute Myocardial Infarction.

Pan-Lizcano R, Marinas-Pardo L, Nunez L, Rebollal-Leal F, Lopez-Vazquez D, Pereira A Int J Mol Sci. 2022; 23(24).

PMID: 36555767 PMC: 9786046. DOI: 10.3390/ijms232416127.

References

Wang X, Shi L . Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis. J Zhejiang Univ Sci B. 2014; 15(3):256-63. PMC: 3955912. DOI: 10.1631/jzus.B1300088. View

Daraei A, Mansoori Y, Zendebad Z, Tavakkoly-Bazzaz J, Madadizadeh F, Naghizadeh M . Influences of IL-1b-3953 C>T and MMP-9-1562C >T Gene Variants on Myocardial Infarction Susceptibility in a Subset of the Iranian Population. Genet Test Mol Biomarkers. 2016; 21(1):33-38. DOI: 10.1089/gtmb.2016.0240. View

Sternlicht M, Werb Z . How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001; 17:463-516. PMC: 2792593. DOI: 10.1146/annurev.cellbio.17.1.463. View

Koh Y, Chang K, Kim P, Seung K, Baek S, Shin W . A close relationship between functional polymorphism in the promoter region of matrix metalloproteinase-9 and acute myocardial infarction. Int J Cardiol. 2007; 127(3):430-2. DOI: 10.1016/j.ijcard.2007.04.107. View

Smith Jr S, Allen J, Blair S, Bonow R, Brass L, Fonarow G . AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update endorsed by the National Heart, Lung, and Blood Institute. J Am Coll Cardiol. 2006; 47(10):2130-9. DOI: 10.1016/j.jacc.2006.04.026. View

Newby A . Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev. 2004; 85(1):1-31. DOI: 10.1152/physrev.00048.2003. View

Brinckerhoff C, Matrisian L . Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol. 2002; 3(3):207-14. DOI: 10.1038/nrm763. View

Brown D, Hibbs M, Kearney M, Loushin C, Isner J . Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation. 1995; 91(8):2125-31. DOI: 10.1161/01.cir.91.8.2125. View

Abd El-Aziz T, Mohamed R . Matrix metalloproteinase -9 polymorphism and outcome after acute myocardial infarction. Int J Cardiol. 2016; 227:524-528. DOI: 10.1016/j.ijcard.2016.10.109. View

10.

Williams S, Hsu F, Keene K, Chen W, Nelson S, Southerland A . Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. Neurology. 2016; 86(4):351-9. PMC: 4776093. DOI: 10.1212/WNL.0000000000002319. View

11.

Beaudoin M, Gupta R, Won H, Lo K, Do R, Henderson C . Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Arterioscler Thromb Vasc Biol. 2015; 35(6):1472-1479. PMC: 4441556. DOI: 10.1161/ATVBAHA.115.305534. View

12.

Johnson J, Fritsche-Danielson R, Behrendt M, Westin-Eriksson A, Wennbo H, Herslof M . Effect of broad-spectrum matrix metalloproteinase inhibition on atherosclerotic plaque stability. Cardiovasc Res. 2006; 71(3):586-95. DOI: 10.1016/j.cardiores.2006.05.009. View

13.

Rodriguez-Perez J, Vargas-Alarcon G, Posadas-Sanchez R, Zagal-Jimenez T, Ortiz-Alarcon R, Valente-Acosta B . rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients. Genet Mol Res. 2016; 15(1):15017776. DOI: 10.4238/gmr.15017776. View

14.

Horne B, Camp N, Carlquist J, Muhlestein J, Kolek M, Nicholas Z . Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease. Am Heart J. 2007; 154(4):751-8. PMC: 2730201. DOI: 10.1016/j.ahj.2007.06.030. View

15.

Galis Z, Khatri J . Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res. 2002; 90(3):251-62. View

16.

Wang J, Xu D, Wu X, Zhou C, Wang H, Guo Y . Polymorphisms of matrix metalloproteinases in myocardial infarction: a meta-analysis. Heart. 2011; 97(19):1542-6. DOI: 10.1136/heartjnl-2011-300342. View

17.

Boateng S, Sanborn T . Acute myocardial infarction. Dis Mon. 2013; 59(3):83-96. DOI: 10.1016/j.disamonth.2012.12.004. View

18.

Antman E, Cohen M, Bernink P, McCabe C, Horacek T, Papuchis G . The TIMI risk score for unstable angina/non-ST elevation MI: A method for prognostication and therapeutic decision making. JAMA. 2000; 284(7):835-42. DOI: 10.1001/jama.284.7.835. View

19.

Morgan A, Zhang B, Tapper W, Collins A, Ye S . Haplotypic analysis of the MMP-9 gene in relation to coronary artery disease. J Mol Med (Berl). 2003; 81(5):321-6. DOI: 10.1007/s00109-003-0441-z. View

20.

Nuzzo D, Vasto S, Balistreri C, Di-Carlo D, Listi F, Caimi G . Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily. Ann N Y Acad Sci. 2007; 1089:496-501. DOI: 10.1196/annals.1386.048. View