Synthesis and Encapsulation of Extract with Zeolitic Imidazolate Framework-8 and Their Therapeutic Action Against G and G Drug-Resistant Bacteria

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2022 Jan 24

PMID 35071862

Authors

Ab Majeed Ahanger

Suresh Kumar

Atul Arya

Amrita Suryavanshi

Dolly Kain

Vandana

Affiliations

Soon will be listed here.

Abstract

Infectious diseases caused by bacteria have become a public health issue. Antibiotic therapy for infectious disorders, as well as antibiotic overuse, has resulted in antibiotic-resistant bacterial strains. Zeolitic imidazolate framework-8 (ZIF-8) possesses a wide surface area, high porosity, variable functionality, and potential drug carriers. We have established a clear method for making a nanoscale APE@ZIF-8 nanocomposite agent with outstanding antibacterial activity against methicillin-resistant (MRSA) and cephalosporin-carbapenem-resistant (CCREC). We present a unique approach for encapsulating molecules of extract (APE) with ZIF-8. APE@ZIF-8 has a positive charge. By electrostatic contact with the negatively charged bacterial surface of and , APE@ZIF-8 NPs produce reactive oxygen species (ROS) that damage bacterial cell organelles. As a result, the APE@ZIF-8 nanocomposite offers limitless application potential in the treatment of infectious disorders caused by drug-resistant gram-positive and gram-negative bacteria.

Citing Articles

Advancing Nanoscale Science: Synthesis and Bioprinting of Zeolitic Imidazole Framework-8 for Enhanced Anti-Infectious Therapeutic Efficacies.

Saif M, Hasan M, Zafar A, Ahmed M, Tariq T, Waqas M Biomedicines. 2023; 11(10).

PMID: 37893205 PMC: 10604899. DOI: 10.3390/biomedicines11102832.

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