and Recurrence of Metabolic Dysfunction-associated Fatty Liver Disease After Liver Transplantation

Overview

Journal World J Hepatol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2022 Jan 24

PMID 35070003

Authors

Ma Ai Thanda Han

Raquel Olivo

Catherine J Choi

Nikolaos Pyrsopoulos

Affiliations

Soon will be listed here.

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new acronym adopted from the consensus of international experts. Given the increasing prevalence of MAFLD in pre-transplant settings, and recurrent graft steatosis/MAFLD are common in post-transplant settings. The impact of graft steatosis on long-term outcomes is unclear. The current knowledge of incidence rate, risk factors, diagnosis, long-term outcomes, and management of graft steatosis (both and recurrent) is discussed in this review.

Citing Articles

Effect of Immunosuppressive Regimens on Metabolic Dysfunction-associated Fatty Liver Disease Following Liver Transplantation.

Kang J, Zhu J, Wang Y, He Q J Clin Exp Hepatol. 2024; 15(1):102387.

PMID: 39268481 PMC: 11388780. DOI: 10.1016/j.jceh.2024.102387.

Metabolic Disorders in Liver Transplant Recipients: The State of the Art.

Gabrielli F, Golfieri L, Nascimbeni F, Andreone P, Gitto S J Clin Med. 2024; 13(4).

PMID: 38398327 PMC: 10889804. DOI: 10.3390/jcm13041014.

Post-Transplant Hepatic Steatosis: A Condition Not to Overlook.

Alabdul Razzak I, Curry M, Lai M, Trivedi H J Clin Med. 2023; 12(23).

PMID: 38068392 PMC: 10707640. DOI: 10.3390/jcm12237340.

MAFLD: an optimal framework for understanding liver cancer phenotypes.

Crane H, Gofton C, Sharma A, George J J Gastroenterol. 2023; 58(10):947-964.

PMID: 37470858 PMC: 10522746. DOI: 10.1007/s00535-023-02021-7.

References

Kirk E, Reeds D, Finck B, Mayurranjan S, Mayurranjan M, Patterson B . Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009; 136(5):1552-60. PMC: 2677125. DOI: 10.1053/j.gastro.2009.01.048. View

Salomone F, Sharaiha R, Boskoski I . Endoscopic bariatric and metabolic therapies for non-alcoholic fatty liver disease: Evidence and perspectives. Liver Int. 2020; 40(6):1262-1268. DOI: 10.1111/liv.14441. View

Lee J, Kim D, Kim H, Lee C, Yang J, Kim W . Hepatic steatosis index: a simple screening tool reflecting nonalcoholic fatty liver disease. Dig Liver Dis. 2009; 42(7):503-8. DOI: 10.1016/j.dld.2009.08.002. View

Watt K, Pedersen R, Kremers W, Heimbach J, Charlton M . Evolution of causes and risk factors for mortality post-liver transplant: results of the NIDDK long-term follow-up study. Am J Transplant. 2010; 10(6):1420-7. PMC: 2891375. DOI: 10.1111/j.1600-6143.2010.03126.x. View

Burra P, Becchetti C, Germani G . NAFLD and liver transplantation: Disease burden, current management and future challenges. JHEP Rep. 2020; 2(6):100192. PMC: 7607500. DOI: 10.1016/j.jhepr.2020.100192. View

Sharma P, Arora A . Approach to prevention of non-alcoholic fatty liver disease after liver transplantation. Transl Gastroenterol Hepatol. 2020; 5:51. PMC: 7530313. DOI: 10.21037/tgh.2020.03.02. View

Bhati C, Idowu M, Sanyal A, Rivera M, Driscoll C, Stravitz R . Long-term Outcomes in Patients Undergoing Liver Transplantation for Nonalcoholic Steatohepatitis-Related Cirrhosis. Transplantation. 2017; 101(8):1867-1874. DOI: 10.1097/TP.0000000000001709. View

Bhagat V, Mindikoglu A, Nudo C, Schiff E, Tzakis A, Regev A . Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease. Liver Transpl. 2009; 15(12):1814-20. DOI: 10.1002/lt.21927. View

Contos M, Cales W, Sterling R, Luketic V, Shiffman M, Mills A . Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis. Liver Transpl. 2001; 7(4):363-73. DOI: 10.1053/jlts.2001.23011. View

10.

Diwan T, Rice T, Heimbach J, Schauer D . Liver Transplantation and Bariatric Surgery: Timing and Outcomes. Liver Transpl. 2018; 24(9):1280-1287. DOI: 10.1002/lt.25303. View

11.

Charlton M . Evolving aspects of liver transplantation for nonalcoholic steatohepatitis. Curr Opin Organ Transplant. 2013; 18(3):251-8. DOI: 10.1097/MOT.0b013e3283615d30. View

12.

Charlton M, Rinella M, Patel D, McCague K, Heimbach J, Watt K . Everolimus Is Associated With Less Weight Gain Than Tacrolimus 2 Years After Liver Transplantation: Results of a Randomized Multicenter Study. Transplantation. 2017; 101(12):2873-2882. PMC: 5704647. DOI: 10.1097/TP.0000000000001913. View

13.

Singh S, Venkatesh S, Keaveny A, Adam S, Miller F, Asbach P . Diagnostic accuracy of magnetic resonance elastography in liver transplant recipients: A pooled analysis. Ann Hepatol. 2016; 15(3):363-76. PMC: 5032623. DOI: 10.5604/16652681.1198808. View

14.

Bhat M, Sonenberg N, Gores G . The mTOR pathway in hepatic malignancies. Hepatology. 2013; 58(2):810-8. PMC: 3688698. DOI: 10.1002/hep.26323. View

15.

Lee V, Miller F, Omary R, Wang Y, Ganger D, Wang E . Magnetic resonance elastography and biomarkers to assess fibrosis from recurrent hepatitis C in liver transplant recipients. Transplantation. 2011; 92(5):581-6. DOI: 10.1097/TP.0b013e31822805fa. View

16.

Eslam M, Sanyal A, George J . MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease. Gastroenterology. 2020; 158(7):1999-2014.e1. DOI: 10.1053/j.gastro.2019.11.312. View

17.

. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016; 64(6):1388-402. DOI: 10.1016/j.jhep.2015.11.004. View

18.

VanWagner L, Bhave M, Te H, Feinglass J, Alvarez L, Rinella M . Patients transplanted for nonalcoholic steatohepatitis are at increased risk for postoperative cardiovascular events. Hepatology. 2012; 56(5):1741-50. DOI: 10.1002/hep.25855. View

19.

Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L . Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gastroenterology. 2015; 149(2):367-78.e5. DOI: 10.1053/j.gastro.2015.04.005. View

20.

Sprinzl M, Weinmann A, Lohse N, Tonissen H, Koch S, Schattenberg J . Metabolic syndrome and its association with fatty liver disease after orthotopic liver transplantation. Transpl Int. 2012; 26(1):67-74. DOI: 10.1111/j.1432-2277.2012.01576.x. View