Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer

Overview

Journal J Cancer

Specialty Oncology

Date 2022 Jan 24

PMID 35069913

Authors

Yixi Su

Qiang Huang

Li Lu

Hu Qu

Dejuan Wang

Jianguang Qiu

Weiqian Li

Mengmeng Lin

Huanliang Liu

Zhongyang Wang

Xiangling Yang

Affiliations

Soon will be listed here.

Abstract

Neuronal pentraxin 2 (NPTX2), a secretory protein of neuronal pentraxins, was first identified in the nervous system. Several studies have shown that expression levels of NPTX2 are associated with the development of various cancers. However, whether NPTX2 is involved in prostate cancer progression is unclear. Herein, we found that NPTX2 is significantly reduced in prostate cancer tissues and cancer cell lines compared to control prostate tissues and control prostatic epithelial cell lines. Furthermore, the NPTX2 promoter is highly methylated in prostate cancer cells. Consistently, NPTX2 could be restored by treatment with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (decitabine, 5-AZA-dC). Overexpression of NPTX2 inhibited prostate cancer cell proliferation both and . In conclusion, our study demonstrated that NPTX2 acts as a tumor suppressor gene in prostate cancer.

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