Endometriosis and Gynaecological Cancers: Molecular Insights Behind a Complex Machinery

Overview

Journal Prz Menopauzalny

Publisher Termedia

Date 2022 Jan 24

PMID 35069072

Authors

Vaclav Vetvicka

Ludek Fiala

Simone Garzon

Giovanni Buzzaccarini

Milan Terzic

Antonio Simone Lagana

Affiliations

Soon will be listed here.

Abstract

Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased migration. It is one of the leading causes of morbidity among premenopausal women, with a prevalence of 10-16% of women of reproductive age. Despite over century of intensive research, none of the current treatment options represents a real cure. Based on the current knowledge, endometriosis, particularly its atypical version, is considered to be a transitional form from benign disease to tumour. However, the exact mechanisms of this conversion are still not fully established.

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