A Sciatic Nerve Gap-injury Model in the Rabbit

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2022 Jan 21

PMID 35061121

Authors

Antonio Merolli

Michelle Li

Gregory Voronin

Lauren Bright

Affiliations

Soon will be listed here.

Abstract

There has been an increased number of studies of nerve transection injuries with the sciatic nerve gap-injury model in the rabbit in the past 2 years. We wanted to define in greater detail what is needed to test artificial nerve guides in a sciatic nerve gap-injury model in the rabbit. We hope that this will help investigators to fully exploit the robust translational potential of the rabbit sciatic nerve gap-injury model in its capacity to test devices whose diameter and length are in the range of those commonly applied in hand and wrist surgery (diameter ranging between 2 and 4 mm; length up to 30 mm). We suggest that the rabbit model should replace the less translational rat model in nerve regeneration research. The rabbit sciatic model, however, requires an effective strategy to prevent and control self-mutilation of the foot in the postoperative period, and to prevent pressure ulcers.

Citing Articles

Biomechanical Evaluation of an Atraumatic Polymer-assisted Peripheral Nerve Repair System Compared with Conventional Neurorrhaphy Techniques.

Wlodarczyk A, Collin E, Pereira M, Bindra R, Power D Plast Reconstr Surg Glob Open. 2024; 12(9):e6151.

PMID: 39267729 PMC: 11392492. DOI: 10.1097/GOX.0000000000006151.

Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect.

Gisbert Roca F, Santos L, Roig M, Medina L, Martinez-Ramos C, Monleon Pradas M Biomedicines. 2022; 10(5).

PMID: 35625700 PMC: 9138968. DOI: 10.3390/biomedicines10050963.

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