Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

Overview

Journal Nutrients

Date 2022 Jan 21

PMID 35057482

Authors

Chidambaram Ramanathan

Thomas Lackie

Drake H Williams

Paul S Simone

Yufeng Zhang

Richard J Bloomer

Affiliations

Soon will be listed here.

Abstract

As a redox-sensitive coenzyme, nicotinamide adenine dinucleotide (NAD) plays a central role in cellular energy metabolism and homeostasis. Low NAD levels are linked to multiple disease states, including age-related diseases, such as metabolic and neurodegenerative diseases. Consequently, restoring/increasing NAD levels in vivo has emerged as an important intervention targeting age-related neurodegenerative diseases. One of the widely studied approaches to increase NAD levels in vivo is accomplished by using NAD precursors, such as nicotinamide mononucleotide (NMN). Oral administration of NMN has been shown to successfully increase NAD levels in a variety of tissues; however, it remains unclear whether NMN can cross the blood-brain barrier to increase brain NAD levels. This study evaluated the effects of oral NMN administration on NAD levels in C57/B6J mice brain tissues. Our results demonstrate that oral gavage of 400 mg/kg NMN successfully increases brain NAD levels in mice after 45 min. These findings provide evidence that NMN may be used as an intervention to increase NAD levels in the brain.

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