Evaluation of Antibacterial and Antifungal Properties of Low Molecular Weight Chitosan Extracted from Relative to Crab Chitosan

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Jan 21

PMID 35056890

Authors

Adelya Khayrova

Sergey Lopatin

Balzhima Shagdarova

Olga Sinitsyna

Arkady Sinitsyn

Valery Varlamov

Affiliations

Soon will be listed here.

Abstract

This study shows the research on the depolymerisation of insect and crab chitosans using novel enzymes. Enzyme preparations containing recombinant chitinase Chi 418 from , chitinase Chi 403, and chitosanase Chi 402 from , all belonging to the family GH18 of glycosyl hydrolases, were used to depolymerise a biopolymer, resulting in a range of chitosans with average molecular weights (M) of 6-21 kDa. The depolymerised chitosans obtained from crustaceans and insects were studied, and their antibacterial and antifungal properties were evaluated. The results proved the significance of the chitosan's origin, showing the potential of as a new source of low molecular weight chitosan with an improved biological activity.

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