Acute Pneumonia Caused by Clinically Isolated Sg 1, ST 62: Host Responses and Pathologies in Mice

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Jan 21

PMID 35056629

Authors

Jiri Trousil

Lucia Frgelecova

Pavla Kubickova

Kristina Rehakova

Vladimir Drasar

Jana Matejkova

Petr Stepanek

Oto Pavlis

Affiliations

Soon will be listed here.

Abstract

Legionnaires' disease is a severe form of lung infection caused by bacteria belonging to the genus . The disease severity depends on both host immunity and virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 10 and 10 CFU, and their impact on the mouse status, bacterial clearance, lung pathology, and blood count parameters was studied. Acute pneumonia resembling Legionnaires' disease has been described in detail.

References

McClure E, Oliva Chavez A, Shaw D, Carlyon J, Ganta R, Noh S . Engineering of obligate intracellular bacteria: progress, challenges and paradigms. Nat Rev Microbiol. 2017; 15(9):544-558. PMC: 5557331. DOI: 10.1038/nrmicro.2017.59. View

Aeffner F, Bolon B, Davis I . Mouse Models of Acute Respiratory Distress Syndrome: A Review of Analytical Approaches, Pathologic Features, and Common Measurements. Toxicol Pathol. 2015; 43(8):1074-92. DOI: 10.1177/0192623315598399. View

Sommer J, Erbguth F, Neundorfer B . Acute disseminated encephalomyelitis following Legionella pneumophila infection. Eur Neurol. 2000; 44(3):182-4. DOI: 10.1159/000008231. View

CARRINGTON C . Pathology of Legionnaires' disease. Ann Intern Med. 1979; 90(4):496-9. DOI: 10.7326/0003-4819-90-4-496. View

Di Bonaventura G, Pompilio A, Zappacosta R, Petrucci F, Fiscarelli E, Rossi C . Role of excessive inflammatory response to Stenotrophomonas maltophilia lung infection in DBA/2 mice and implications for cystic fibrosis. Infect Immun. 2010; 78(6):2466-76. PMC: 2876550. DOI: 10.1128/IAI.01391-09. View

Li L, Zhang L, Wu H, Qu P, Chen J, Zhan X . sp. nov., isolated from aquatic environments in the northern PR China. Int J Syst Evol Microbiol. 2020; 71(1). DOI: 10.1099/ijsem.0.004592. View

Brieland J, Loebenberg D, Menzel F, Hare R . Efficacy of SCH27899 in an animal model of Legionnaires' disease using immunocompromised A/J mice. Antimicrob Agents Chemother. 2000; 44(5):1333-6. PMC: 89864. DOI: 10.1128/AAC.44.5.1333-1336.2000. View

Davis G, Winn Jr W, Gump D, Craighead J, Beaty H . Legionnaires' pneumonia after aerosol exposure in guinea pigs and rats. Am Rev Respir Dis. 1982; 126(6):1050-7. DOI: 10.1164/arrd.1982.126.6.1050. View

Graham F, Hales S, White P, Baker M . Review Global seroprevalence of legionellosis - a systematic review and meta-analysis. Sci Rep. 2020; 10(1):7337. PMC: 7193644. DOI: 10.1038/s41598-020-63740-y. View

10.

Chastre J, Raghu G, Soler P, Brun P, Basset F, Gibert C . Pulmonary fibrosis following pneumonia due to acute Legionnaires' disease. Clinical, ultrastructural, and immunofluorescent study. Chest. 1987; 91(1):57-62. DOI: 10.1378/chest.91.1.57. View

11.

Marx G . Fluid therapy in sepsis with capillary leakage. Eur J Anaesthesiol. 2003; 20(6):429-42. DOI: 10.1017/s0265021503000681. View

12.

Brieland J, Remick D, Freeman P, Hurley M, Fantone J, Engleberg N . In vivo regulation of replicative Legionella pneumophila lung infection by endogenous tumor necrosis factor alpha and nitric oxide. Infect Immun. 1995; 63(9):3253-8. PMC: 173448. DOI: 10.1128/iai.63.9.3253-3258.1995. View

13.

David S, Mentasti M, Tewolde R, Aslett M, Harris S, Afshar B . Evaluation of an Optimal Epidemiological Typing Scheme for Legionella pneumophila with Whole-Genome Sequence Data Using Validation Guidelines. J Clin Microbiol. 2016; 54(8):2135-48. PMC: 4963484. DOI: 10.1128/JCM.00432-16. View

14.

Harrison T, Afshar B, Doshi N, Fry N, Lee J . Distribution of Legionella pneumophila serogroups, monoclonal antibody subgroups and DNA sequence types in recent clinical and environmental isolates from England and Wales (2000-2008). Eur J Clin Microbiol Infect Dis. 2009; 28(7):781-91. DOI: 10.1007/s10096-009-0705-9. View

15.

Helbig J, Bernander S, Pastoris M, Etienne J, Gaia V, Lauwers S . Pan-European study on culture-proven Legionnaires' disease: distribution of Legionella pneumophila serogroups and monoclonal subgroups. Eur J Clin Microbiol Infect Dis. 2002; 21(10):710-6. DOI: 10.1007/s10096-002-0820-3. View

16.

Fukushi M, Yamashita M, Miyoshi-Akiyama T, Kubo S, Yamamoto K, Kudo K . Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with lethal influenza H1N1 Virus. PLoS One. 2012; 7(8):e42419. PMC: 3409853. DOI: 10.1371/journal.pone.0042419. View

17.

Paudel S, Baral P, Ghimire L, Bergeron S, Jin L, DeCorte J . CXCL1 regulates neutrophil homeostasis in pneumonia-derived sepsis caused by serotype 3. Blood. 2019; 133(12):1335-1345. PMC: 6428667. DOI: 10.1182/blood-2018-10-878082. View

18.

Reichardt K, Jacobs E, Roske I, Helbig J . Legionella pneumophila carrying the virulence-associated lipopolysaccharide epitope possesses two functionally different LPS components. Microbiology (Reading). 2010; 156(Pt 10):2953-2961. DOI: 10.1099/mic.0.039933-0. View

19.

Osadnik T, Bujak K, Osadnik K, Czarnecka H, Pawlas N, Regula R . Novel inflammatory biomarkers may reflect subclinical inflammation in young healthy adults with obesity. Endokrynol Pol. 2019; 70(2):135-142. DOI: 10.5603/EP.a2019.0002. View

20.

Chitasombat M, Ratchatanawin N, Visessiri Y . Disseminated extrapulmonary Legionella pneumophila infection presenting with panniculitis: case report and literature review. BMC Infect Dis. 2018; 18(1):467. PMC: 6142325. DOI: 10.1186/s12879-018-3378-0. View