Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site During Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime-Avibactam-Based Regimens: A Report of Two Cases

Overview

Journal Microorganisms

Specialty Microbiology

Date 2022 Jan 21

PMID 35056602

Authors

Milo Gatti

Giulio Virgili

Pier Giorgio Cojutti

Paolo Gaibani

Matteo Conti

Carmelo Sturiale

Federico Pea

Pierluigi Viale

Affiliations

Soon will be listed here.

Abstract

We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful.

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