The Bovine Tuberculoid Granuloma

Overview

Journal Pathogens

Date 2022 Jan 21

PMID 35056009

Authors

Mitchell V Palmer

Carly Kanipe

Paola M Boggiatto

Affiliations

Soon will be listed here.

Abstract

The bovine tuberculoid granuloma is the hallmark lesion of bovine tuberculosis (bTB) due to infection. The pathogenesis of bTB, and thereby the process of bovine tuberculoid granuloma development, involves the recruitment, activation, and maintenance of cells under the influence of antigen, cytokines and chemokines in affected lungs and regional lymph nodes. The granuloma is key to successful control of bTB by preventing pathogen dissemination through containment by cellular and fibrotic layers. Paradoxically, however, it may also provide a niche for bacterial replication. The morphologic and cellular characteristics of granulomas have been used to gauge disease severity in bTB pathogenesis and vaccine efficacy studies. As such, it is critical to understand the complex mechanisms behind granuloma initiation, development, and maintenance.

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