Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Jan 21

PMID 35054151

Authors

Salvatore De Rosa

Claudio Iaconetti

Ceren Eyileten

Masakazu Yasuda

Michele Albanese

Alberto Polimeni

Jolanda Sabatino

Sabato Sorrentino

Marek Postula

Ciro Indolfi

Affiliations

Soon will be listed here.

Abstract

The vascular system is largely exposed to the effect of changing flow conditions. Vascular cells can sense flow and its changes. Flow sensing is of pivotal importance for vascular remodeling. In fact, it influences the development and progression of atherosclerosis, controls its location and has a major influx on the development of local complications. Despite its importance, the research community has traditionally paid scarce attention to studying the association between different flow conditions and vascular biology. More recently, a growing body of evidence has been accumulating, revealing that ncRNAs play a key role in the modulation of several biological processes linking flow-sensing to vascular pathophysiology. This review summarizes the most relevant evidence on ncRNAs that are directly or indirectly responsive to flow conditions to the benefit of the clinician, with a focus on the underpinning mechanisms and their potential application as disease biomarkers.

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