Effects of Chronic Intranasal Dantrolene on Nasal Mucosa Morphology in Mice

Overview

Journal Eur Rev Med Pharmacol Sci

Specialties General Medicine
Pharmacology
Toxicology

Date 2022 Jan 20

PMID 35048995

Authors

B Jiang

Y Shi

M B Abou

L Xu

G Liang

H Wei

Affiliations

Soon will be listed here.

Abstract

Objective: We have previously shown that the intranasal administration of dantrolene ameliorated cognitive dysfunction in the 5XFAD mouse model of Alzheimer's disease. This study examines the morphology of the nasal mucosa after 10 months of intranasal dantrolene in 5XFAD mice.

Materials And Methods: 5XFAD mice were either treated with intranasal dantrolene (5 mg/kg, 3 times/wk) from 2 months to 12 months of age or given no treatment at all. The mice were euthanatized at 12 months of age and the snouts were processed for histological examination. The morphology of the nasal mucosa was assessed and compared between the two groups.

Results: There were no significant differences in the thickness of the olfactory epithelium or the proportion of the thickness of the glandular layer to the wall of mucosa and submucosa in the nasal passages.

Conclusions: Long-term intranasal administration of dantrolene did not significantly change the nasal mucosa morphology in 5XFAD mice.

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