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Dupilumab-associated Head and Neck Dermatitis is Associated with Elevated Pretreatment Serum Malassezia-specific IgE: a Multicentre, Prospective Cohort Study

Overview
Journal Br J Dermatol
Specialty Dermatology
Date 2022 Jan 18
PMID 35041759
Authors
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Abstract

Dupilumab associated head and neck dermatitis is incompletely understood. This prospective multicentre prospective study identified baseline Malassezia-specific IgE as associated with the development of Dupilumab associated head and neck dermatitis.

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References
1.
Darabi K, Grim Hostetler S, Bechtel M, Zirwas M . The role of Malassezia in atopic dermatitis affecting the head and neck of adults. J Am Acad Dermatol. 2008; 60(1):125-36. DOI: 10.1016/j.jaad.2008.07.058. View

2.
de Wijs L, Nguyen N, Kunkeler A, Nijsten T, Damman J, Hijnen D . Clinical and histopathological characterization of paradoxical head and neck erythema in patients with atopic dermatitis treated with dupilumab: a case series. Br J Dermatol. 2019; 183(4):745-749. PMC: 7586932. DOI: 10.1111/bjd.18730. View

3.
Jo C, Finstad A, Georgakopoulos J, Piguet V, Yeung J, Drucker A . Facial and neck erythema associated with dupilumab treatment: A systematic review. J Am Acad Dermatol. 2021; 84(5):1339-1347. DOI: 10.1016/j.jaad.2021.01.012. View

4.
de Beer F, Bakker D, Haeck I, Ariens L, Van der Schaft J, van Dijk M . Dupilumab facial redness: Positive effect of itraconazole. JAAD Case Rep. 2019; 5(10):888-891. PMC: 6818397. DOI: 10.1016/j.jdcr.2019.07.020. View

5.
Muzumdar S, Zubkov M, Waldman R, DeWane M, Wu R, Grant-Kels J . Characterizing dupilumab facial redness in children and adolescents: A single-institution retrospective chart review. J Am Acad Dermatol. 2020; 83(5):1520-1521. DOI: 10.1016/j.jaad.2020.06.1003. View