Chronic Cough in Germany: Results from a General-population Survey

Overview

Journal ERJ Open Res

Specialty Pulmonary Medicine

Date 2022 Jan 17

PMID 35036416

Authors

J Christian Virchow

Vicky W Li

Eileen Fonseca

Helena Salmen

Ashley Martin

Joanne Brady

Christina Jannowitz

Jonathan Schelfhout

Affiliations

Soon will be listed here.

Abstract

Background: Chronic cough (CC) which is defined ≥8 weeks is a common condition in clinical practice. However, estimates of prevalence and associated comorbidities in German adults and key subgroups of age and gender are lacking.

Methods: Cross-sectional study based on a representative panel of 15 020 adult subjects of the general population who completed the German National Health and Wellness Survey, reporting CC and questions about comorbidities. Lifetime and 12-month prevalence are presented as unweighted estimates.

Results: The lifetime CC prevalence was 6.5% (range across age groups 5.1%-8.3%) and the 12-month prevalence was 4.9% (range 3.7-5.7%). The prevalence of diagnosed CC was 2.8% (range 0.9-4.1%) and the prevalence of persons currently on any prescription to treat CC was 0.6% (range 0.2-1.4%). Respondents who experienced CC were 52.0±17.0 years old, with a higher prevalence in those aged 50 years and older. Persons with CC had higher morbidity scores and were diagnosed with an increased number of comorbidities, most frequently diagnoses of the respiratory system (71.0%), followed by digestive tract disorders (34.0%) and sleep disorders (37.6%).

Conclusions: In a broadly representative sample of German adults, lifetime and 12-month prevalence of CC was greatest in current and former smokers and those older ≥50 years of age. Comorbidities are frequent and may complicate management of these patients.

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References

Spitzer R, Kroenke K, Williams J, Lowe B . A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006; 166(10):1092-7. DOI: 10.1001/archinte.166.10.1092. View

DiBonaventura M, Wagner J, Yuan Y, LItalien G, Langley P, Kim W . Humanistic and economic impacts of hepatitis C infection in the United States. J Med Econ. 2010; 13(4):709-18. DOI: 10.3111/13696998.2010.535576. View

McGarvey L, Gibson P . What Is Chronic Cough? Terminology. J Allergy Clin Immunol Pract. 2019; 7(6):1711-1714. DOI: 10.1016/j.jaip.2019.04.012. View

Morice A, Millqvist E, Belvisi M, Bieksiene K, Birring S, Chung K . Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. Eur Respir J. 2014; 44(5):1132-48. DOI: 10.1183/09031936.00218613. View

Kardos P, Dinh Q, Fuchs K, Gillissen A, Klimek L, Koehler M . German Respiratory Society guidelines for diagnosis and treatment of adults suffering from acute, subacute and chronic cough. Respir Med. 2020; 170:105939. DOI: 10.1016/j.rmed.2020.105939. View

Zeiger R, Schatz M, Butler R, Weaver J, Bali V, Chen W . Burden of Specialist-Diagnosed Chronic Cough in Adults. J Allergy Clin Immunol Pract. 2020; 8(5):1645-1657.e7. DOI: 10.1016/j.jaip.2020.01.054. View

Finkelstein E, Allaire B, DiBonaventura M, Burgess S . Direct and indirect costs and potential cost savings of laparoscopic adjustable gastric banding among obese patients with diabetes. J Occup Environ Med. 2011; 53(9):1025-9. DOI: 10.1097/JOM.0b013e318229aae4. View

Chan K, Ing A, Laks L, Cossa G, Rogers P, Birring S . Chronic cough in patients with sleep-disordered breathing. Eur Respir J. 2010; 35(2):368-72. DOI: 10.1183/09031936.00110409. View

Ware Jr J, Sherbourne C . The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992; 30(6):473-83. View

10.

Brazier J, Roberts J, Deverill M . The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002; 21(2):271-92. DOI: 10.1016/s0167-6296(01)00130-8. View

11.

Ford A, Forman D, Moayyedi P, Morice A . Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms. Thorax. 2006; 61(11):975-9. PMC: 2121176. DOI: 10.1136/thx.2006.060087. View

12.

Arinze J, de Roos E, Karimi L, Verhamme K, Stricker B, Brusselle G . Prevalence and incidence of, and risk factors for chronic cough in the adult population: the Rotterdam Study. ERJ Open Res. 2020; 6(2). PMC: 7167208. DOI: 10.1183/23120541.00300-2019. View

13.

Dicpinigaitis P, Tso R, Banauch G . Prevalence of depressive symptoms among patients with chronic cough. Chest. 2006; 130(6):1839-43. DOI: 10.1378/chest.130.6.1839. View

14.

Colak Y, Nordestgaard B, Laursen L, Afzal S, Lange P, Dahl M . Risk Factors for Chronic Cough Among 14,669 Individuals From the General Population. Chest. 2017; 152(3):563-573. DOI: 10.1016/j.chest.2017.05.038. View

15.

Irwin R, Baumann M, Bolser D, Boulet L, Braman S, Brightling C . Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest. 2006; 129(1 Suppl):1S-23S. PMC: 3345522. DOI: 10.1378/chest.129.1_suppl.1S. View

16.

Satia I, Mayhew A, Sohel N, Kurmi O, Killian K, OByrne P . Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging. ERJ Open Res. 2021; 7(2). PMC: 8093484. DOI: 10.1183/23120541.00160-2021. View

17.

Hinz A, Mehnert A, Kocalevent R, Brahler E, Forkmann T, Singer S . Assessment of depression severity with the PHQ-9 in cancer patients and in the general population. BMC Psychiatry. 2016; 16:22. PMC: 4736493. DOI: 10.1186/s12888-016-0728-6. View

18.

Irwin R, French C, Chang A, Altman K . Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report. Chest. 2017; 153(1):196-209. PMC: 6689094. DOI: 10.1016/j.chest.2017.10.016. View

19.

Pratter M . Unexplained (idiopathic) cough: ACCP evidence-based clinical practice guidelines. Chest. 2006; 129(1 Suppl):220S-221S. DOI: 10.1378/chest.129.1_suppl.220S. View

20.

Bolge S, Doan J, Kannan H, Baran R . Association of insomnia with quality of life, work productivity, and activity impairment. Qual Life Res. 2009; 18(4):415-22. DOI: 10.1007/s11136-009-9462-6. View