Research Advances in the Role and Pharmaceuticals of ATP-binding Cassette Transporters in Autoimmune Diseases

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2022 Jan 16

PMID 35034257

Authors

Jun Yu

Hao Chen

Jiangmei Xu

Peng Zhou

Affiliations

Soon will be listed here.

Abstract

Autoimmune diseases are caused by the immune response of the body to its antigens, resulting in tissue damage. The pathogenesis of these diseases has not yet been elucidated. Most autoimmune diseases cannot be cured by effective drugs. The treatment strategy is to relieve the symptoms of the disease and balance the body's autoimmune function. The abnormal expression of ATP-binding cassette (ABC) transporters is directly related to the pathogenesis of autoimmune diseases and drug therapy resistance, which poses a great challenge for the drug therapy of autoimmune diseases. Therefore, this paper reviews the interplay between ABC transporters and the pathogenesis of autoimmune diseases to provide research progress and new ideas for the development of drugs in autoimmune diseases.

Citing Articles

Dysfunction of ABC Transporters at the Surface of BBB: Potential Implications in Intractable Epilepsy and Applications of Nanotechnology Enabled Drug Delivery.

Mohi-Ud-Din R, Mir R, Ahad Mir P, Banday N, Shah A, Sawhney G Curr Drug Metab. 2022; 23(9):735-756.

PMID: 35980054 DOI: 10.2174/1389200223666220817115003.

References

Rahman S, Mchaourab H . ATP-dependent interactions of a cargo protein with the transmembrane domain of a polypeptide processing and secretion ABC transporter. J Biol Chem. 2020; 295(43):14678-14685. PMC: 7586231. DOI: 10.1074/jbc.RA120.014934. View

Mandal S, Adhikari R, Sharma A, Chandravanshi M, Gogoi P, Kanaujia S . Designating ligand specificities to metal uptake ABC transporters in Thermus thermophilus HB8. Metallomics. 2019; 11(3):597-612. DOI: 10.1039/c8mt00374b. View

Schmitt L, Tampe R . Structure and mechanism of ABC transporters. Curr Opin Struct Biol. 2002; 12(6):754-60. DOI: 10.1016/s0959-440x(02)00399-8. View

Stefan S . Multi-target ABC transporter modulators: what next and where to go?. Future Med Chem. 2019; 11(18):2353-2358. DOI: 10.4155/fmc-2019-0185. View

Tucker T, Milne A, Fournel-Gigleux S, Fenner K, Coughtrie M . Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum. Biochem Pharmacol. 2011; 83(2):279-85. DOI: 10.1016/j.bcp.2011.10.017. View

van de Water F, Boleij J, Peters J, Russel F, Masereeuw R . Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines. Eur J Pharm Sci. 2006; 30(1):36-44. DOI: 10.1016/j.ejps.2006.09.008. View

Yu J, Zhou P, Asenso J, Yang X, Wang C, Wei W . Advances in plant-based inhibitors of P-glycoprotein. J Enzyme Inhib Med Chem. 2016; 31(6):867-81. DOI: 10.3109/14756366.2016.1149476. View

Langan D, Rose N, Moudgil K . Common innate pathways to autoimmune disease. Clin Immunol. 2020; 212:108361. PMC: 8324042. DOI: 10.1016/j.clim.2020.108361. View

Carroll M . Innate immunity in the etiopathology of autoimmunity. Nat Immunol. 2001; 2(12):1089-90. DOI: 10.1038/ni1201-1089. View

10.

Zhang H, Xu H, Ashby Jr C, Assaraf Y, Chen Z, Liu H . Chemical molecular-based approach to overcome multidrug resistance in cancer by targeting P-glycoprotein (P-gp). Med Res Rev. 2020; 41(1):525-555. DOI: 10.1002/med.21739. View

11.

Chen F, Yao Q, Liu H, Fang P . Evaluation on the germplasm of maize (Zea mays L.) landraces from southwest China. Genet Mol Res. 2017; 15(4). DOI: 10.4238/gmr15049160. View

12.

Sava G, Fan H, Fisher R, Lusvarghi S, Pancholi S, Ambudkar S . ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942. Oncogene. 2019; 39(3):651-663. PMC: 6962093. DOI: 10.1038/s41388-019-1008-y. View

13.

Kang H, Malinen M, Saran C, Honkakoski P, Brouwer K . Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions. Drug Metab Dispos. 2019; 47(10):1222-1230. PMC: 6756293. DOI: 10.1124/dmd.119.087676. View

14.

Zolnerciks J, Andress E, Nicolaou M, Linton K . Structure of ABC transporters. Essays Biochem. 2011; 50(1):43-61. DOI: 10.1042/bse0500043. View

15.

Ling V, Thompson L . Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J Cell Physiol. 1974; 83(1):103-16. DOI: 10.1002/jcp.1040830114. View

16.

Arana M, Altenberg G . ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1. Curr Med Chem. 2017; 26(7):1062-1078. DOI: 10.2174/0929867324666171012105143. View

17.

Gottesman M, Fojo T, Bates S . Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2002; 2(1):48-58. DOI: 10.1038/nrc706. View

18.

Ambudkar S, Dey S, Hrycyna C, Ramachandra M, Pastan I, Gottesman M . Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol. 1999; 39:361-98. DOI: 10.1146/annurev.pharmtox.39.1.361. View

19.

Matsson P, Pedersen J, Norinder U, Bergstrom C, Artursson P . Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs. Pharm Res. 2009; 26(8):1816-31. DOI: 10.1007/s11095-009-9896-0. View

20.

Raub T . P-glycoprotein recognition of substrates and circumvention through rational drug design. Mol Pharm. 2006; 3(1):3-25. DOI: 10.1021/mp0500871. View