Immunomodulatory Effects of Mesenchymal Stem Cells in Peripheral Nerve Injury

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2022 Jan 16

PMID 35033187

Authors

Xiangling Li

Yanjun Guan

Chaochao Li

Tieyuan Zhang

Fanqi Meng

Jian Zhang

Junyang Li

Shengfeng Chen

Qi Wang

Yi Wang

Jiang Peng

Jinshu Tang

Affiliations

Soon will be listed here.

Abstract

Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI.

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