4-Amino-1,8-naphthalimide-ferrocene Conjugates As Potential Multi-targeted Anticancer and Fluorescent Cellular Imaging Agents

Overview

Journal RSC Med Chem

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 Jan 14

PMID 35028564

Authors

Alex D Johnson

Joseph A Buhagiar

David C Magri

Affiliations

Soon will be listed here.

Abstract

Herein we present eight ferrocenyl 4-amino-1,8-naphthalimides. Designed as fluorescent logic gates for acidity and oxidisability, the molecules have been repurposed as anti-proliferation and cellular imaging agents. The compounds were studied against MCF-7 and K562 cancer cell lines by the MTT method. Compounds with protonable secondary amines tended to exhibit greater cytotoxicity than those with tertiary amines. Compounds with no measurable GI values within a 24 hour time window, as well as at shorter exposure times, may be suitable as fluorescent cellular imaging probes.

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