Smoking Habits and Gallbladder Disease: a Systematic Review and Meta-analysis Study

Overview

Journal Hippokratia

Specialty General Medicine

Date 2022 Jan 13

PMID 35023890

Authors

V Papadopoulos

D Filippou

K Mimidis

Affiliations

Soon will be listed here.

Abstract

Background: It has been claimed that smoking is linked with an increased risk for gallbladder disease (GBD); however, related issues need further consolidation and clarification. The present systematic review and meta-analysis aimed to further investigate the potent correlation between GBD and smoking.

Methods: We conducted a comprehensive literature review to identify every study published from January 1989 to December 2019, reporting risk estimates regarding GBD and smoking. The random-effect, generic inverse variance method, according to description by DerSimonian and Laird, was used to compute pooled estimates. We used the Newcastle-Ottawa quality assessment scale to appraise the included studies' quality.

Results: Thirty published case-control, cross-sectional, and cohort studies including 4,623,435 individuals met the eligibility criteria and were considered for data synthesis. Compared to the non-smokers, ever smokers had 1.25 times higher odds of developing GBD [95 % confidence interval (CI): 1.09-1.44]; however, increased heterogeneity was observed (I =96 %, 95 % CI: 62-100 %, p <0.001). Publication bias was non-significant (Eggers' regression p =0.072). The main sources of heterogeneity, as detected by meta-regression analyzing study characteristics, biases and confounders, were non-adjustment for family history (p =0.007) and alcohol (p =0.020), respectively. Subgroup analysis indicated a comparable risk for GBD as far as current, former and ever smokers are concerned (p =0.520). Quantitative analysis suggested a dose-effect for current smoking and GBD (p =0.010).

Conclusions: Non-smokers were demonstrated to be at a lower risk of presenting GBD when compared with ever smokers; all relevant risk estimates necessitate adjustment for family history and alcohol intake. HIPPOKRATIA 2020, 24(4): 147-156.

References

Shabanzadeh D . New determinants for gallstone disease? . Dan Med J. 2018; 65(2). View

Okamoto M, Yamagata Z, Takeda Y, Yoda Y, Kobayashi K, A Fujino M . The relationship between gallbladder disease and smoking and drinking habits in middle-aged Japanese. J Gastroenterol. 2002; 37(6):455-62. DOI: 10.1007/s005350200066. View

Wang S, Wang Y, Xu J, Chen Y . Is the oral contraceptive or hormone replacement therapy a risk factor for cholelithiasis: A systematic review and meta-analysis. Medicine (Baltimore). 2017; 96(14):e6556. PMC: 5411213. DOI: 10.1097/MD.0000000000006556. View

Stinton L, Shaffer E . Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver. 2012; 6(2):172-87. PMC: 3343155. DOI: 10.5009/gnl.2012.6.2.172. View

Shabanzadeh D, Sorensen L, Jorgensen T . Determinants for gallstone formation - a new data cohort study and a systematic review with meta-analysis. Scand J Gastroenterol. 2016; 51(10):1239-48. DOI: 10.1080/00365521.2016.1182583. View

Shea B, Reeves B, Wells G, Thuku M, Hamel C, Moran J . AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017; 358:j4008. PMC: 5833365. DOI: 10.1136/bmj.j4008. View

Yamada M, Wong F, Fujiwara S, Tatsukawa Y, Suzuki G . Smoking and alcohol habits as risk factors for benign digestive diseases in a Japanese population: the radiation effects research foundation adult health study. Digestion. 2005; 71(4):231-7. DOI: 10.1159/000087048. View

Grodstein F, Colditz G, Hunter D, Manson J, Willett W, Stampfer M . A prospective study of symptomatic gallstones in women: relation with oral contraceptives and other risk factors. Obstet Gynecol. 1994; 84(2):207-14. View

Greenland S, Longnecker M . Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol. 1992; 135(11):1301-9. DOI: 10.1093/oxfordjournals.aje.a116237. View

10.

Kono S, Shinchi K, TODOROKI I, Honjo S, Sakurai Y, Wakabayashi K . Gallstone disease among Japanese men in relation to obesity, glucose intolerance, exercise, alcohol use, and smoking. Scand J Gastroenterol. 1995; 30(4):372-6. DOI: 10.3109/00365529509093293. View

11.

Kato I, Nomura A, STEMMERMANN G, Chyou P . Prospective study of clinical gallbladder disease and its association with obesity, physical activity, and other factors. Dig Dis Sci. 1992; 37(5):784-90. DOI: 10.1007/BF01296440. View

12.

Hedges L, Tipton E, Johnson M . Robust variance estimation in meta-regression with dependent effect size estimates. Res Synth Methods. 2015; 1(1):39-65. DOI: 10.1002/jrsm.5. View

13.

Aune D, Leitzmann M, Vatten L . Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies. J Phys Act Health. 2016; 13(7):788-95. DOI: 10.1123/jpah.2015-0456. View

14.

Sahi T, Paffenbarger Jr R, Hsieh C, Lee I . Body mass index, cigarette smoking, and other characteristics as predictors of self-reported, physician-diagnosed gallbladder disease in male college alumni. Am J Epidemiol. 1998; 147(7):644-51. DOI: 10.1093/oxfordjournals.aje.a009505. View

15.

Volzke H, Baumeister S, Alte D, Hoffmann W, Schwahn C, Simon P . Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005; 71(2):97-105. DOI: 10.1159/000084525. View

16.

Walcher T, Haenle M, Mason R, Koenig W, Imhof A, Kratzer W . The effect of alcohol, tobacco and caffeine consumption and vegetarian diet on gallstone prevalence. Eur J Gastroenterol Hepatol. 2010; 22(11):1345-51. DOI: 10.1097/MEG.0b013e32833efdb2. View

17.

Gonzalez-Perez A, Garcia Rodriguez L . Gallbladder disease in the general population: association with cardiovascular morbidity and therapy. Pharmacoepidemiol Drug Saf. 2006; 16(5):524-31. DOI: 10.1002/pds.1346. View

18.

Aune D, Norat T, Vatten L . Body mass index, abdominal fatness and the risk of gallbladder disease. Eur J Epidemiol. 2015; 30(9):1009-19. DOI: 10.1007/s10654-015-0081-y. View

19.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

20.

Jorgensen T . Gall stones in a Danish population. Relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus. Gut. 1989; 30(4):528-34. PMC: 1434027. DOI: 10.1136/gut.30.4.528. View