Concepts of Advanced Therapeutic Delivery Systems for the Management of Remodeling and Inflammation in Airway Diseases

Overview

Journal Future Med Chem

Specialties Chemistry
Pharmacy

Date 2022 Jan 12

PMID 35019757

Authors

Daljeet Singh Dhanjal

Parvarish Sharma

Meenu Mehta

Murtaza M Tambuwala

Parteek Prasher

Keshav R Paudel

Gang Liu

Shakti D Shukla

Philip M Hansbro

Dinesh Kumar Chellappan

Kamal Dua

Saurabh Satija

Affiliations

Soon will be listed here.

Abstract

Chronic respiratory disorders affect millions of people worldwide. Pathophysiological changes to the normal airway wall structure, including changes in the composition and organization of its cellular and molecular constituents, are referred to as airway remodeling. The inadequacy of effective treatment strategies and scarcity of novel therapies available for the treatment and management of chronic respiratory diseases have given rise to a serious impediment in the clinical management of such diseases. The progress made in advanced drug delivery, has offered additional advantages to fight against the emerging complications of airway remodeling. This review aims to address the gaps in current knowledge about airway remodeling, the relationships between remodeling, inflammation, clinical phenotypes and the significance of using novel drug delivery methods.

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