A Cortical Cell Ensemble in the Posterior Parietal Cortex Controls Past Experience-dependent Memory Updating

Overview

Journal Nat Commun

Specialty Biology

Date 2022 Jan 12

PMID 35017495

Authors

Akinobu Suzuki

Sakurako Kosugi

Emi Murayama

Eri Sasakawa

Noriaki Ohkawa

Ayumu Konno

Hirokazu Hirai

Kaoru Inokuchi

Affiliations

Soon will be listed here.

Abstract

When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.

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