Inositol Deficiency in Saccharomyces Cerevisiae NCYC 86

Overview

Journal Antonie Van Leeuwenhoek

Publisher Springer

Specialty Microbiology

Date 1978 Jan 1

PMID 350147

Citations 7

Authors

A Dominguez

J R VILLANUEVA

R Sentandreu

Affiliations

Soon will be listed here.

Abstract

When Saccharomyces cerevisiae NCYC 86, an inositol dependent strain, is grown at suboptimal concentrations of inositol, the buds are apparently unable to separate from the parent cells. Thin sections of such cells show an irregularly thickened cell wall. These morphological features may be due to a continuation or increase in the production of glucan while the synthesis of DNA, RNA, phospholipids.and protein is greatly inhibited.

Citing Articles

A myo-inositol bioassay utilizing an auxotrophic strain of S. cerevisiae.

Suliman M, Schmidtke M, Greenberg M J Microbiol Methods. 2021; 189:106300.

PMID: 34389363 PMC: 8464524. DOI: 10.1016/j.mimet.2021.106300.

Mutants of Saccharomyces cerevisiae cell division cycle defective in cytokinesis. Biosynthesis of the cell wall and morphology.

Dominguez A, Varona R, VILLANUEVA J, Sentandreu R Antonie Van Leeuwenhoek. 1982; 48(2):145-57.

PMID: 7049082 DOI: 10.1007/BF00405199.

Effects of inositol starvation on phospholipid and glycan syntheses in Saccharomyces cerevisiae.

Hanson B, Lester R J Bacteriol. 1980; 142(1):79-89.

PMID: 6989811 PMC: 293906. DOI: 10.1128/jb.142.1.79-89.1980.

Effect of inositol starvation on the in vitro syntheses of mannan and N-acetylglucosaminylpyrophosphoryldolichol in Saccharomyces cerevisiae.

Hanson B, Lester R J Bacteriol. 1982; 151(1):334-42.

PMID: 6177681 PMC: 220245. DOI: 10.1128/jb.151.1.334-342.1982.

Ultrastructure and cell wall composition in cell division cycle mutants of Schizosaccharomyces pombe deficient in septum formation.

Mateos P, Dominguez A Antonie Van Leeuwenhoek. 1991; 59(3):155-65.

PMID: 1867471 DOI: 10.1007/BF00580655.

References

Ghosh A, CHARALAMPOUS F, SISON Y, BORER R . Metabolic function of myo-inositol. I. Cytological and chemical alterations in yeast resulting from inositol deficiency. J Biol Chem. 1960; 235:2522-8. View

Sentandreu R, ELORZA M, VILLANUEVA J . Synthesis of yeast wall glucan. J Gen Microbiol. 1975; 90(1):13-20. DOI: 10.1099/00221287-90-1-13. View

NECAS O . Cell wall synthesis in yeast protoplasts. Bacteriol Rev. 1971; 35(2):149-70. PMC: 378379. DOI: 10.1128/br.35.2.149-170.1971. View

CHALLINOR S, Power D, TONGE R . EFFECTS OF INOSITOL-DEFICIENCY ON YEAST WITH PARTICULAR REFERENCE TO CHEMICAL COMPOSITION OF THE CELL AND OF THE CELL WALL. Nature. 1964; 203:250-1. DOI: 10.1038/203250a0. View

Hartwell L . Periodic density fluctuation during the yeast cell cycle and the selection of synchronous cultures. J Bacteriol. 1970; 104(3):1280-5. PMC: 248288. DOI: 10.1128/jb.104.3.1280-1285.1970. View

ELORZA M, Sentandreu R . Effect of cycloheximide on yeast cell wall synthesis. Biochem Biophys Res Commun. 1969; 36(5):741-7. DOI: 10.1016/0006-291x(69)90672-x. View

Lewin L . Effects of meso-inositol deficiency on some important biological and chemical characteristics of yeast. J Gen Microbiol. 1965; 41(2):215-24. DOI: 10.1099/00221287-41-2-215. View

Arnold W . The structure of the yeast cell wall. Solubilization of a marker enzyme, -fructofuranosidase, by the autolytic enzyme system. J Biol Chem. 1972; 247(4):1161-9. View

Reynolds E . The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963; 17:208-12. PMC: 2106263. DOI: 10.1083/jcb.17.1.208. View

10.

Gander J . Fungal cell wall glycoproteins and peptido-polysaccharides. Annu Rev Microbiol. 1974; 28(0):103-19. DOI: 10.1146/annurev.mi.28.100174.000535. View

11.

ELORZA M, Lostau C, VILLANUEVA J, Sentandreu R . Cell wall synthesis regulation in Saccharomyces cerevisiae. Effect of RNA and protein inhibition. Biochim Biophys Acta. 1976; 454(2):263-72. DOI: 10.1016/0005-2787(76)90229-x. View

12.

Sentandreu R, Northcote D . The formation of buds in yeast. J Gen Microbiol. 1969; 55(3):393-8. DOI: 10.1099/00221287-55-3-393. View

13.

Power D, CHALLINOR S . The effects of inositol-deficiency on the chemical composition of the yeast cell wall. J Gen Microbiol. 1969; 55(2):169-76. DOI: 10.1099/00221287-55-2-169. View

14.

Sentandreu R, Northcote D . Yeast cell-wall synthesis. Biochem J. 1969; 115(2):231-40. PMC: 1185094. DOI: 10.1042/bj1150231. View

15.

Higgins M, Boothby D, SHOCKMAN G . Effect of inhibition of deoxyribonucleic acid and protein synthesis on the direction of cell wall growth in Streptococcus faecalis. J Bacteriol. 1974; 118(2):681-92. PMC: 246803. DOI: 10.1128/jb.118.2.681-692.1974. View

16.

Johnston J, Paltauf F . Lipid metabolism in inositol-deficient yeast, Saccharomyces carlsbergensis. II. Incorporation of labeled precursors into lipids by whole cells and activities of some enzymes involved in lipid formation. Biochim Biophys Acta. 1970; 218(3):431-40. View

17.

RIDGWAY G, DOUGLAS H . Unbalanced growth of yeast due to inositol deficiency. J Bacteriol. 1958; 76(2):163-6. PMC: 290179. DOI: 10.1128/jb.76.2.163-166.1958. View