Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine As Inhibitors of β-Glucuronidase Efficacy

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Jan 11

PMID 35012128

Authors

Valerii D Krasikov

Yulia G Santuryan

Irina I Malahova

Alexey G Ivanov

Nikolay I Gorshkov

Evgenii F Panarin

Affiliations

Soon will be listed here.

Abstract

Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.

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